Prognostic significance of six autoantibodies in esophageal squamous cell carcinoma: A prospective multi-institutional study

IF 2.9 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of Gastroenterological Surgery Pub Date : 2025-01-16 DOI:10.1002/ags3.12910

Fumiaki Shiratori, Naoto Fujiwara, Yasuaki Nakajima, Koji Otsuka, Masahiko Murakami, Satoru Matsuda, Hirofumi Kawakubo, Keita Takahashi, Yuichiro Tanishima, Daiji Oka, Shunichi Ito, Kosuke Narumiya, Osamu Aramaki, Tadatoshi Takayama, Takashi Suzuki, Satoshi Yajima, Hideaki Shimada

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Abstract

Aim

Serum autoantibodies have been reported to react with tumor-associated antigens in various cancers. This study evaluated the diagnostic and prognostic significance of six autoantibody panels in esophageal squamous cell carcinoma.

Methods

In this study, 193 patients with esophageal squamous cell carcinoma and 78 healthy controls were enrolled. Serum antibodies were detected using originally developed enzyme-linked immunosorbent assays to detect autoantibodies against the following tumor antigens: c-myc, p62, RalA, p53, Sui1, and NY-ESO-1. The positive rates of the six-autoantibody panel were compared with those of SCC antigen (SCC-Ag). The prognostic significance of these autoantibodies was also evaluated.

Results

The overall positive rate was significantly higher in the six-autoantibody panel than in SCC-Ag (72% vs. 28%; p < 0.01). The positive rates of the six-autoantibody panel were 71% in stage 0/I, 73% in stage II, and 71% in stage III. No clinicopathological factors were associated with autoantibodies. Although the difference was not significant, the overall survival of the autoantibody-positive group was worse than that of the autoantibody-negative group (p = 0.14).

Conclusion

The six-autoantibody panel was useful for detecting esophageal squamous cell carcinoma, particularly in stage 0/I; however, it showed limited prognostic significance.

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六种自身抗体在食管鳞状细胞癌中的预后意义：一项前瞻性多机构研究

目的血清自身抗体在多种肿瘤中与肿瘤相关抗原发生反应。本研究评价了六种自身抗体对食管鳞状细胞癌的诊断和预后意义。方法选择193例食管鳞状细胞癌患者和78名健康对照。采用最初开发的酶联免疫吸附法检测血清抗体，检测针对以下肿瘤抗原的自身抗体：c-myc、p62、RalA、p53、Sui1和NY-ESO-1。比较六抗体组与SCC抗原（SCC- ag）的阳性率。这些自身抗体的预后意义也进行了评估。结果6自身抗体组的总阳性率明显高于SCC-Ag组(72% vs. 28%；p < 0.01)。6个自身抗体组的阳性率在0/I期为71%，II期为73%，III期为71%。无临床病理因素与自身抗体相关。虽然差异不显著，但自身抗体阳性组的总生存率低于自身抗体阴性组（p = 0.14）。结论6抗体对食管鳞状细胞癌的检测有较好的效果，特别是在0/I期；然而，它显示有限的预后意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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