One step NaOH etched-modified pencil graphite for electrochemical sensing of dopamine neurotransmitter

IF 5.1 3区材料科学 Q2 MATERIALS SCIENCE, COATINGS & FILMS

Diamond and Related Materials Pub Date : 2025-06-27 DOI:10.1016/j.diamond.2025.112596

Deepti , Mahe Taiba Hussain , Partha Sarathi Mondal , Amitesh Kumar , Subrata Majumder

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Abstract

The electrochemical oxidation of dopamine in aqueous solutions at a pencil graphite electrode etched with sodium hydroxide (NaOH) was investigated using cyclic and anodic stripping voltammetric methods. In order to modify the pencil graphite, a 10 V DC power supply was applied for 40 min in the presence of 0.1 M NaOH. The modified electrode has been characterized by X-ray diffraction, field emission scanning electron microscopy, Ultraviolet-visible (UV–Vis), and Raman spectroscopy techniques. The redox reaction was assessed with the variable scan rates. In phosphate buffer at pH = 7.0, well-resolved voltammetric peaks (against silver/silver chloride) were produced for analytical purposes. The modified sensor electrode offered a sensitivity of 1.333 × 10⁻² mA/pM/cm⁻² in measuring the dopamine molecules with concentrations ranging from 13.3 pM to 105.5 pM and successfully achieved the lowest detection limit of 13.3 pM. The suggested electrode also exhibited superior stability and selectivity in the presence of other interfering biomolecules.

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一步氢氧化钠蚀刻改性铅笔石墨电化学感应多巴胺神经递质

采用循环伏安法和阳极溶出伏安法研究了水溶液中多巴胺在氢氧化钠（NaOH）蚀刻铅笔石墨电极上的电化学氧化。为了修饰铅笔石墨，在0.1 M NaOH存在下，用10 V直流电源供电40 min。用x射线衍射、场发射扫描电子显微镜、紫外可见（UV-Vis）和拉曼光谱技术对修饰电极进行了表征。用可变扫描速率评价氧化还原反应。在pH = 7.0的磷酸盐缓冲液中，产生了很好分辨的伏安峰（针对银/氯化银）用于分析目的。在13.3 ~ 105.5 pM范围内，该传感器电极的灵敏度为1.333 × 10−2 mA/pM/cm−2，最低检测限为13.3 pM。所建议的电极在其他干扰生物分子存在下也表现出优异的稳定性和选择性。

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来源期刊

Diamond and Related Materials 工程技术-材料科学：综合

CiteScore

6.00

自引率

14.60%

发文量

702

审稿时长

2.1 months

期刊介绍： DRM is a leading international journal that publishes new fundamental and applied research on all forms of diamond, the integration of diamond with other advanced materials and development of technologies exploiting diamond. The synthesis, characterization and processing of single crystal diamond, polycrystalline films, nanodiamond powders and heterostructures with other advanced materials are encouraged topics for technical and review articles. In addition to diamond, the journal publishes manuscripts on the synthesis, characterization and application of other related materials including diamond-like carbons, carbon nanotubes, graphene, and boron and carbon nitrides. Articles are sought on the chemical functionalization of diamond and related materials as well as their use in electrochemistry, energy storage and conversion, chemical and biological sensing, imaging, thermal management, photonic and quantum applications, electron emission and electronic devices. The International Conference on Diamond and Carbon Materials has evolved into the largest and most well attended forum in the field of diamond, providing a forum to showcase the latest results in the science and technology of diamond and other carbon materials such as carbon nanotubes, graphene, and diamond-like carbon. Run annually in association with Diamond and Related Materials the conference provides junior and established researchers the opportunity to exchange the latest results ranging from fundamental physical and chemical concepts to applied research focusing on the next generation carbon-based devices.