Inflammatory biomarkers to predict clinical outcomes in adults after cardiac surgery in China: a prospective observational trial

IF 3.7 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zhengqin Liu, Qian Zhai
{"title":"Inflammatory biomarkers to predict clinical outcomes in adults after cardiac surgery in China: a prospective observational trial","authors":"Zhengqin Liu,&nbsp;Qian Zhai","doi":"10.1016/j.cyto.2025.156987","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Systemic inflammatory response syndrome (SIRS) is a common occurrence in patients following cardiac surgery which has potential in the prediction of adverse postoperative outcomes. This study sought to investigate the underlying association between perioperative inflammatory cytokine levels and clinical outcomes in adults undergoing cardiac surgery.</div></div><div><h3>Methods</h3><div>This prospective study included 2100 patients admitted to the cardiovascular surgery intensive care unit between September 1, 2023, to August 31, 2024. Serum levels of nine inflammatory biomarkers (IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12p70, IL-17, TNF-α, and IFN-γ) were measured preoperatively and on the first postoperative day. Biomarker comparisons between groups (patients with and without postoperative complications) were assessed using receiver operating characteristic (ROC) curve analysis. Multivariable logistic regression was employed to identify independent risk factors for 30-day mortality prolonged, mechanical ventilation (MV) and postoperative acute kidney injury (AKI), adjusting for confounders such as cardiopulmonary bypass (CPB) type and other perioperative variables.</div></div><div><h3>Results</h3><div>Among the 2100 patients, 272 (13.0 %) required prolonged MV, 374 (17.8 %) developed AKI, and 40 (1.9 %) died within 30 days postoperatively. Significant differences in IL-6, IL-12p70, and IFN-γ levels were found between patients grouped by CPB type. Elevated levels of IL-6, IL-10, IL-17, and IFN-γ were observed in patients with prolonged MV, while patients who developed AKI had higher levels of IL-6, IL-2, and IL-10. Notably, IL-10 was the only cytokine significantly elevated in non-survivors compared to survivors. The area under the curve (AUC) for predicting prolonged MV was 0.654 for IL-6, 0.649 for IL-10, 0.668 for IL-17, and 0.644 for IFN-γ. For AKI, the AUC was 0.649 for IL-6, 0.623 for IL-2, and 0.684 for IL-10. The AUC for predicting 30-day mortality was 0.810 for IL-10. Multivariable logistic regression identified IL-6, IFN-γ, and APACHE II score as independent risk factors for prolonged MV, while IL-2 and 24-h postoperative drainage were independent risk factors for AKI. None cytokines were found to be associated with 30-day mortality except for APACHE II and SOFA score.</div></div><div><h3>Conclusions</h3><div>Elevated postoperative inflammatory biomarkers, particularly IL-6, IL-10, and IFN-γ, are associated with worse clinical outcomes, including prolonged MV, AKI, and 30-day mortality. Identifying these biomarkers early may help stratify patients at higher risk of poor outcomes after cardiac surgery.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"193 ","pages":"Article 156987"},"PeriodicalIF":3.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cytokine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1043466625001346","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Systemic inflammatory response syndrome (SIRS) is a common occurrence in patients following cardiac surgery which has potential in the prediction of adverse postoperative outcomes. This study sought to investigate the underlying association between perioperative inflammatory cytokine levels and clinical outcomes in adults undergoing cardiac surgery.

Methods

This prospective study included 2100 patients admitted to the cardiovascular surgery intensive care unit between September 1, 2023, to August 31, 2024. Serum levels of nine inflammatory biomarkers (IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12p70, IL-17, TNF-α, and IFN-γ) were measured preoperatively and on the first postoperative day. Biomarker comparisons between groups (patients with and without postoperative complications) were assessed using receiver operating characteristic (ROC) curve analysis. Multivariable logistic regression was employed to identify independent risk factors for 30-day mortality prolonged, mechanical ventilation (MV) and postoperative acute kidney injury (AKI), adjusting for confounders such as cardiopulmonary bypass (CPB) type and other perioperative variables.

Results

Among the 2100 patients, 272 (13.0 %) required prolonged MV, 374 (17.8 %) developed AKI, and 40 (1.9 %) died within 30 days postoperatively. Significant differences in IL-6, IL-12p70, and IFN-γ levels were found between patients grouped by CPB type. Elevated levels of IL-6, IL-10, IL-17, and IFN-γ were observed in patients with prolonged MV, while patients who developed AKI had higher levels of IL-6, IL-2, and IL-10. Notably, IL-10 was the only cytokine significantly elevated in non-survivors compared to survivors. The area under the curve (AUC) for predicting prolonged MV was 0.654 for IL-6, 0.649 for IL-10, 0.668 for IL-17, and 0.644 for IFN-γ. For AKI, the AUC was 0.649 for IL-6, 0.623 for IL-2, and 0.684 for IL-10. The AUC for predicting 30-day mortality was 0.810 for IL-10. Multivariable logistic regression identified IL-6, IFN-γ, and APACHE II score as independent risk factors for prolonged MV, while IL-2 and 24-h postoperative drainage were independent risk factors for AKI. None cytokines were found to be associated with 30-day mortality except for APACHE II and SOFA score.

Conclusions

Elevated postoperative inflammatory biomarkers, particularly IL-6, IL-10, and IFN-γ, are associated with worse clinical outcomes, including prolonged MV, AKI, and 30-day mortality. Identifying these biomarkers early may help stratify patients at higher risk of poor outcomes after cardiac surgery.

Abstract Image

炎症生物标志物预测中国成人心脏手术后临床结果:一项前瞻性观察性试验
背景:全身性炎症反应综合征(SIRS)在心脏手术后患者中很常见,在预测术后不良结果方面具有潜力。本研究旨在探讨成人心脏手术围手术期炎症细胞因子水平与临床结果之间的潜在关系。方法本前瞻性研究纳入2023年9月1日至2024年8月31日在心血管外科重症监护病房住院的2100例患者。术前及术后第一天检测9种炎症生物标志物(IL-1β、IL-2、IL-4、IL-6、IL-10、IL-12p70、IL-17、TNF-α、IFN-γ)的血清水平。采用受试者工作特征(ROC)曲线分析评估各组(有无术后并发症的患者)之间的生物标志物比较。采用多变量logistic回归确定30天死亡率延长、机械通气(MV)和术后急性肾损伤(AKI)的独立危险因素,并对体外循环(CPB)类型和其他围手术期变量等混杂因素进行调整。结果2100例患者中,272例(13.0%)需要延长MV, 374例(17.8%)发生AKI, 40例(1.9%)在术后30天内死亡。不同CPB类型患者之间IL-6、IL-12p70、IFN-γ水平差异有统计学意义。在MV延长患者中观察到IL-6、IL-10、IL-17和IFN-γ水平升高,而AKI患者的IL-6、IL-2和IL-10水平较高。值得注意的是,与幸存者相比,IL-10是唯一在非幸存者中显著升高的细胞因子。IL-6、IL-10、IL-17和IFN-γ的曲线下面积(AUC)分别为0.654、0.649、0.668和0.644。对于AKI, IL-6的AUC为0.649,IL-2为0.623,IL-10为0.684。IL-10预测30天死亡率的AUC为0.810。多变量logistic回归发现IL-6、IFN-γ和APACHE II评分是延长MV的独立危险因素,而IL-2和术后24小时引流是AKI的独立危险因素。除APACHE II和SOFA评分外,未发现任何细胞因子与30天死亡率相关。结论:术后炎症生物标志物升高,尤其是IL-6、IL-10和IFN-γ,与较差的临床结果相关,包括延长MV、AKI和30天死亡率。早期识别这些生物标志物可能有助于对心脏手术后预后不良风险较高的患者进行分层。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Cytokine
Cytokine 医学-免疫学
CiteScore
7.60
自引率
2.60%
发文量
262
审稿时长
48 days
期刊介绍: The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信