{"title":"Mechanism of RNA primer removal in plastid DNA replication","authors":"","doi":"10.1038/s41477-025-02038-1","DOIUrl":null,"url":null,"abstract":"The factors involved in the removal of RNA primers during plastid DNA (ptDNA) replication have been unclear. We now identify a plastid-localized 5′–3′ exonuclease (PEN1) that mediates the removal of RNA primers in ptDNA replication and provide structural insight into its mechanism of action in this process.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"129 3 1","pages":""},"PeriodicalIF":15.8000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Plants","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41477-025-02038-1","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The factors involved in the removal of RNA primers during plastid DNA (ptDNA) replication have been unclear. We now identify a plastid-localized 5′–3′ exonuclease (PEN1) that mediates the removal of RNA primers in ptDNA replication and provide structural insight into its mechanism of action in this process.
期刊介绍:
Nature Plants is an online-only, monthly journal publishing the best research on plants — from their evolution, development, metabolism and environmental interactions to their societal significance.