Oral antiretroviral adherence interventions in the era of U=U

IF 13 1区 医学 Q1 IMMUNOLOGY
Claire M Keene PhD, Lora L Sabin PhD, Lauren Jennings MPH, Chantel Schreuder MBChB, Carl-Oscar Källström-Ståhlgren MSc, Ingrid T Katz MD, Yashna Singh MPH, Catherine Orrell PhD, K Rivet Amico PhD
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引用次数: 0

Abstract

Antiretroviral therapy (ART) is a keystone of the public health response to HIV, making the support of adherence a point of focus in research and service delivery. Over the past decade, measurements of viral suppression have increasingly been used to evaluate interventions, with more robust study designs gaining traction. Effective approaches include adherence counselling beyond ART education (including mental health and wellbeing approaches), reducing burden of care, tackling structural and societal determinants of health, and using mHealth platforms to deliver interventions. Increasingly, single-strategy interventions are giving way to multicomponent approaches to respond to nuances in adherence behaviour. However, determining which effective strategy to offer and to whom, when, and how remain pressing questions if professionals in the field (eg, researchers, clinicians, and community health workers) are to reach the UNAIDS 95-95-95 goals in the recent context of decreased funding. As new long-acting treatments enter global formularies, interventions showing success with oral ART will probably remain relevant to inform service delivery in most contexts.
U=U时代的口服抗逆转录病毒依从性干预措施
抗逆转录病毒疗法(ART)是公共卫生应对艾滋病毒的一个基石,使支持坚持治疗成为研究和提供服务的一个重点。在过去的十年中,病毒抑制的测量越来越多地用于评估干预措施,更强大的研究设计获得了牵引力。有效的方法包括抗逆转录病毒治疗教育之外的依从性咨询(包括心理健康和福利方法)、减轻护理负担、解决健康的结构和社会决定因素,以及利用移动健康平台提供干预措施。越来越多的单一策略干预正在让位于多成分方法,以应对依从性行为的细微差别。然而,在最近资金减少的背景下,如果该领域的专业人员(如研究人员、临床医生和社区卫生工作者)要实现艾滋病规划署95-95目标,确定向谁、何时以及如何提供哪种有效战略仍然是紧迫的问题。随着新的长效治疗方法进入全球处方,在口服抗逆转录病毒治疗方面取得成功的干预措施可能仍然与大多数情况下的服务提供有关。
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来源期刊
Lancet Hiv
Lancet Hiv IMMUNOLOGYINFECTIOUS DISEASES&-INFECTIOUS DISEASES
CiteScore
19.90
自引率
4.30%
发文量
368
期刊介绍: The Lancet HIV is an internationally trusted source of clinical, public health, and global health knowledge with an Impact Factor of 16.1. It is dedicated to publishing original research, evidence-based reviews, and insightful features that advocate for change in or illuminates HIV clinical practice. The journal aims to provide a holistic view of the pandemic, covering clinical, epidemiological, and operational disciplines. It publishes content on innovative treatments and the biological research behind them, novel methods of service delivery, and new approaches to confronting HIV/AIDS worldwide. The Lancet HIV publishes various types of content including articles, reviews, comments, correspondences, and viewpoints. It also publishes series that aim to shape and drive positive change in clinical practice and health policy in areas of need in HIV. The journal is indexed by several abstracting and indexing services, including Crossref, Embase, Essential Science Indicators, MEDLINE, PubMed, SCIE and Scopus.
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