Claire M Keene PhD, Lora L Sabin PhD, Lauren Jennings MPH, Chantel Schreuder MBChB, Carl-Oscar Källström-Ståhlgren MSc, Ingrid T Katz MD, Yashna Singh MPH, Catherine Orrell PhD, K Rivet Amico PhD
{"title":"Oral antiretroviral adherence interventions in the era of U=U","authors":"Claire M Keene PhD, Lora L Sabin PhD, Lauren Jennings MPH, Chantel Schreuder MBChB, Carl-Oscar Källström-Ståhlgren MSc, Ingrid T Katz MD, Yashna Singh MPH, Catherine Orrell PhD, K Rivet Amico PhD","doi":"10.1016/s2352-3018(25)00096-7","DOIUrl":null,"url":null,"abstract":"Antiretroviral therapy (ART) is a keystone of the public health response to HIV, making the support of adherence a point of focus in research and service delivery. Over the past decade, measurements of viral suppression have increasingly been used to evaluate interventions, with more robust study designs gaining traction. Effective approaches include adherence counselling beyond ART education (including mental health and wellbeing approaches), reducing burden of care, tackling structural and societal determinants of health, and using mHealth platforms to deliver interventions. Increasingly, single-strategy interventions are giving way to multicomponent approaches to respond to nuances in adherence behaviour. However, determining which effective strategy to offer and to whom, when, and how remain pressing questions if professionals in the field (eg, researchers, clinicians, and community health workers) are to reach the UNAIDS 95-95-95 goals in the recent context of decreased funding. As new long-acting treatments enter global formularies, interventions showing success with oral ART will probably remain relevant to inform service delivery in most contexts.","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"1 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lancet Hiv","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/s2352-3018(25)00096-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Antiretroviral therapy (ART) is a keystone of the public health response to HIV, making the support of adherence a point of focus in research and service delivery. Over the past decade, measurements of viral suppression have increasingly been used to evaluate interventions, with more robust study designs gaining traction. Effective approaches include adherence counselling beyond ART education (including mental health and wellbeing approaches), reducing burden of care, tackling structural and societal determinants of health, and using mHealth platforms to deliver interventions. Increasingly, single-strategy interventions are giving way to multicomponent approaches to respond to nuances in adherence behaviour. However, determining which effective strategy to offer and to whom, when, and how remain pressing questions if professionals in the field (eg, researchers, clinicians, and community health workers) are to reach the UNAIDS 95-95-95 goals in the recent context of decreased funding. As new long-acting treatments enter global formularies, interventions showing success with oral ART will probably remain relevant to inform service delivery in most contexts.
期刊介绍:
The Lancet HIV is an internationally trusted source of clinical, public health, and global health knowledge with an Impact Factor of 16.1. It is dedicated to publishing original research, evidence-based reviews, and insightful features that advocate for change in or illuminates HIV clinical practice. The journal aims to provide a holistic view of the pandemic, covering clinical, epidemiological, and operational disciplines. It publishes content on innovative treatments and the biological research behind them, novel methods of service delivery, and new approaches to confronting HIV/AIDS worldwide. The Lancet HIV publishes various types of content including articles, reviews, comments, correspondences, and viewpoints. It also publishes series that aim to shape and drive positive change in clinical practice and health policy in areas of need in HIV. The journal is indexed by several abstracting and indexing services, including Crossref, Embase, Essential Science Indicators, MEDLINE, PubMed, SCIE and Scopus.