Trends of Non-Hodgkin Lymphoma Incidence Among Adults in the United States From 2000 to 2020

IF 1.5 Q4 ONCOLOGY
Cancer reports Pub Date : 2025-06-30 DOI:10.1002/cnr2.70269
Armin Aslani, Morvarid Najafi, Seyed Ehsan Mousavi, Hanieh Marandi, Zahra Yekta, Seyed Aria Nejadghaderi
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Abstract

Background

Non-Hodgkin lymphoma (NHL) comprises a broad range of hematologic cancers originating from lymphoid tissues. It ranks among the 10 most frequently diagnosed cancers in the United States (US).

Aims

This study aims to analyze trends in the incidence of adult NHL in the US from 2000 to 2020, considering factors such as age, sex, race/ethnicity, and histological subtypes. Additionally, the impact of the COVID-19 pandemic on these incidence trends was explored.

Methods and Results

Data from the Surveillance, Epidemiology, and End Results program were utilized to examine the age-standardized incidence rates (ASIR) of NHL. Joinpoint regression modeling was applied to calculate the annual percent change (APC) and the average annual percent change (AAPC) of ASIRs over the period from 2000 to 2020. From 2000 to 2019, a total of 962 535 NHL were reported among all ages in the US. They were mostly B-cell NHL (93.59%), in Non-Hispanic Whites (73.31%), and individuals aged 70–79 (25.94%). The overall ASIRs were 55.58 (55.43, 55.73) for men and 36.00 (35.89, 36.11) for women. There was a notable decline in ASIRs following the onset of the COVID-19 pandemic from 2019 to November 2020, with a percentage change of −10.52% (−11.60, −9.45). The overall AAPC for adult NHL was 0.45% (0.33, 0.62) in men and 0.38% (0.21, 0.57) in women, indicating a minimal yet significant increase.

Conclusion

NHL incidence increased over 2000–2019. These trends in incidence rates exhibited variation across different races, sexes, age groups, and histological subtypes. COVID-19 led to a decrease in NHL incidence.

Abstract Image

2000 - 2020年美国成人非霍奇金淋巴瘤发病率趋势
背景:非霍奇金淋巴瘤(NHL)包括广泛的起源于淋巴组织的血液学癌症。它是美国10种最常诊断的癌症之一。本研究旨在分析2000年至2020年美国成人NHL发病率的趋势,考虑年龄、性别、种族/民族和组织学亚型等因素。此外,还探讨了COVID-19大流行对这些发病率趋势的影响。方法和结果利用来自监测、流行病学和最终结果项目的数据来检查NHL的年龄标准化发病率(ASIR)。采用联合点回归模型计算了2000 - 2020年asir的年变化百分比(APC)和平均年变化百分比(AAPC)。从2000年到2019年,美国各年龄段共报告了962 535例NHL。主要为b细胞NHL(93.59%)、非西班牙裔白人(73.31%)和70-79岁人群(25.94%)。男性的总体asir为55.58(55.43,55.73),女性为36.00(35.89,36.11)。2019年至2020年11月,新冠肺炎大流行爆发后,asir显著下降,百分比变化幅度为- 10.52%(- 11.60%,- 9.45%)。成人NHL的总体AAPC在男性为0.45%(0.33,0.62),在女性为0.38%(0.21,0.57),虽有微小但显著增加。结论2000-2019年NHL发病率呈上升趋势。这些发病率趋势表现出不同种族、性别、年龄组和组织学亚型的差异。COVID-19导致NHL发病率下降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer reports
Cancer reports Medicine-Oncology
CiteScore
2.70
自引率
5.90%
发文量
160
审稿时长
17 weeks
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