Front Cover Picture: Development of Photo-Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten (Adv. Synth. Catal. 12/2025)

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-06-30 DOI:10.1002/adsc.70018

Natalia Antos, Aleksandra Rudzka, Anna Hoser, Tamara Reiter, Wolfgang Kroutil, Paweł Borowiecki

引用次数: 0

Abstract

Chiral Amines

The cover art (designed by Dr. Paweł Borowiecki and illustrated by Dr. Paulina Marek-Urban) depicts a light-driven biocatalytic cascade uniting photochemistry and enzymatic transformation in a single reaction vessel. Blue LED light initiates photooxidation, followed by asymmetric transamination—symbolized by the flow from light to enzyme. This seamless one-pot process enables the synthesis of enantiopure amines, exemplified by the chiral intermediate en route to the cardiomyopathy drug mavacamten. More information can be found in article number 2500250 by Paweł Borowiecki and co-workers.

Abstract Image

查看原文本刊更多论文

封面图：利用蓝光和转氨酶不对称合成光活性胺的光生物催化氧化还原体系的研究进展。马伐卡坦（Adv. Synth）的个案研究Catal。12/2025)

手性胺封面（由paweowborowiecki博士设计，Paulina Marek-Urban博士绘制）描绘了一个光驱动的生物催化级联反应，将光化学和酶转化结合在一个反应容器中。蓝色LED光启动光氧化，随后是不对称转氨化-象征着从光到酶的流动。这种无缝的一锅工艺使对映纯胺的合成成为可能，例如手性中间体在通往心肌病药物马伐卡坦的途中。更多信息可以在paweowborowiecki及其同事的文章编号2500250中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.