Association Between ACE Gene I/D Polymorphism and Diabetic Retinopathy in Mexican Population

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research Pub Date : 2025-06-30 DOI:10.1016/j.arcmed.2025.103252

Karla Barrera-Perales , Héctor Pérez-Cano , Sergio Rojas-Juárez , Oscar Morales-López , Alin Somilleda-Ventura , Miguel Angel Cuevas-Budhart , Rogelio Ivan Silva Rueda

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Abstract

Background and Aims

Diabetic retinopathy (DR) is a significant ocular complication. The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with its development.

Objective

To evaluate the relationship between the ACE gene I/D polymorphism and the presence of DR to identify the highest-risk allele.

Methods

79 patients with diabetic retinopathy and 75 healthy controls were studied. Metabolic and anthropometric measurements were performed, and DNA was extracted to identify the polymorphism using C-reactive protein. Fisher’s exact test was used for comparative analysis of allele and genotypic frequencies.

Results

The I/I genotype was more frequent in patients with DR (43 %) and was associated with a 3.22-fold increased risk of developing the disease (p = 0.0123). The I allele frequency was 67 % in patients and 56 % in controls, though no significant difference was found (p = 0.073).

Conclusions

The higher frequency of the I/I genotype in patients with DR suggests that this genotype may be a risk factor for developing the disease in patients with type 2 diabetes (T2DM). Further studies are recommended to confirm these findings.

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ACE基因I/D多态性与墨西哥人群糖尿病视网膜病变的关系

背景与目的糖尿病视网膜病变（DR）是一种重要的眼部并发症。血管紧张素转换酶（ACE）基因的插入/缺失（I/D）多态性与ACE的发育有关。目的探讨ACE基因I/D多态性与DR存在的关系，以确定高危等位基因。方法对79例糖尿病视网膜病变患者和75例健康对照者进行研究。进行代谢和人体测量，并提取DNA，利用c反应蛋白鉴定多态性。采用Fisher精确检验法对等位基因和基因型频率进行比较分析。结果I/I基因型在DR患者中更为常见（43%），与发病风险增加3.22倍相关（p = 0.0123）。患者I等位基因频率为67%，对照组为56%，差异无统计学意义（p = 0.073）。结论DR患者中I/I基因型的发生率较高，提示该基因型可能是2型糖尿病（T2DM）患者发病的危险因素。建议进一步的研究来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Medical Research 医学-医学：研究与实验

CiteScore

12.50

自引率

0.00%

发文量

审稿时长

28 days

期刊介绍： Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.