Nanohybrid delivery systems for release of an anti-inflammatory drug based on the magnetic nanocomposites of Mg/Zn-Al layered double hydroxides

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry Pub Date : 2025-07-01 DOI:10.1016/j.rechem.2025.102474

Sorour Bakhshi Sichani, Mohammadreza Mansournia, Fereshteh Abbasi

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Abstract

This research presents a novel approach to prepare the MgAl and ZnAl layered double hydroxides (MgAl-LDH (ML) and ZnAl-LDH (ZL)) as the shell on the core of Fe₃O₄ nanoparticles, followed by investigating the intercalation process of an anti-inflammatory drug, mefenamic acid (mef), and then, utilizing the produced Fe₃O₄@MgAl-LDH (FML) and Fe₃O₄@ZnAl-LDH (FZL) samples in a nanohybrid delivery model. The obtained biocompatible nanostructures were characterized by a range of techniques such as FT-IR, XRD, EDX, SEM, VSM, TEM, and TGA. The enlargement of the interlayer space, revealed by the X-ray diffraction technique, indicated that mef was successfully intercalated into the LDH nanostructures (ML 95.16 %, ZL 95.21 %, FML 93.88 %, and FZL 94.17 %). The surface morphology, examined by the scanning electron microscope images showed the stacked sheet of LDHs. In addition, the drug release properties were studied in PBS buffer (pH = 7.4) at 37 °C and exhibited a sustained release profile. The great rate of 80.03 %, 60.96 %, 82.11 %, and 80.55 % was found after 24 h for ML-mef, ZL-mef, FML-mef, and FZL-mef nanohybrids, respectively. The results revealed that the as-synthesized nanocomposites can play the role of a promising nanocarrier in the targeted and controlling drug release systems.

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基于Mg/Zn-Al层状双氢氧化物磁性纳米复合材料的抗炎药物纳米混合释放系统

本研究提出了一种制备MgAl和ZnAl层状双氢氧化物（MgAl- ldh （ML）和ZnAl- ldh (ZL)）作为Fe3O4纳米颗粒核壳的新方法，然后研究了抗炎药甲氧胺酸（mef）的插层过程，然后利用所制备的Fe3O4@MgAl-LDH （FML）和Fe3O4@ZnAl-LDH （FZL）样品进行纳米混合递送模型。通过FT-IR、XRD、EDX、SEM、VSM、TEM和TGA等一系列技术对所得的生物相容性纳米结构进行了表征。x射线衍射技术显示层间空间的扩大表明mef成功嵌入LDH纳米结构（ML为95.16%，ZL为95.21%，FML为93.88%，FZL为94.17%）。表面形貌，通过扫描电子显微镜图像检查显示堆积的LDHs片。此外，在37°C的PBS缓冲液（pH = 7.4）中研究了药物的释放特性，并显示出缓释特性。24 h后，ML-mef、ZL-mef、FML-mef和FZL-mef纳米杂种的最高成活率分别为80.03%、60.96%、82.11%和80.55%。结果表明，所合成的纳米复合材料在药物靶向和控制释放系统中具有良好的应用前景。

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