End-to-end learning of safe stimulation parameters for cortical neuroprosthetic vision.

Abstract

Objective.Direct electrical stimulation of the brain via cortical visual neuroprostheses is a promising approach to restore basic sight for the visually impaired by inducing a percept of localized light called 'phosphenes'. Apart from the challenge of condensing complex sensory information into meaningful stimulation patterns at low temporal and spatial resolution, providing safe stimulation levels to the brain is crucial.Approach.We propose an end-to-end framework to learn optimal stimulation parameters (amplitude, pulse width and frequency) within safe biological constraints. The learned stimulation parameters are passed to a biologically plausible phosphene simulator which takes into account the size, brightness, and temporal dynamics of perceived phosphenes.Main results.Our experiments on naturalistic navigation videos demonstrate that constraining stimulation parameters to safe levels not only maintains task performance in image reconstruction from phosphenes but consistently results in more meaningful phosphene vision, while providing insights into the optimal range of stimulation parameters.Significance.Our study presents a stimulus-generating encoder that learns stimulation parameters (1) satisfying safety constraints, and (2) maximizing the combined objective of image reconstruction and phosphene interpretability with a highly realistic phosphene simulator accounting for temporal dynamics of stimulation. End-to-end learning of stimulation parameters this way enables enforcement of critical biological safety constraints as well as technical limits of the hardware at hand.