Association between continuous glucose monitoring derived metrics and clinical parameters in Indian people living with type 2 diabetes

IF 2.3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Primary Care Diabetes Pub Date : 2025-10-01 Epub Date: 2025-06-27 DOI:10.1016/j.pcd.2025.06.004

Purvi Chawla , Alpana Sowani , Rakesh Parikh , Amit Gupta , Jothydev Kesavadev , Rutul Gokalani , Banshi Saboo , Manoj Chawla

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引用次数: 0

Abstract

Background

To evaluate the correlation between continuous glucose monitoring (CGM)-derived metrics such as time in range (TIR) and time below range (TBR) and clinical parameters in Indian patients with type 2 diabetes mellitus (T2DM), providing insights into the effectiveness of CGM in this population.

Methods

This is a single-center, retrospective-observational study of T2DM patients aged 18 or older years using the Freestyle Libre/Libre Pro CGM system. Demographic and clinical data of these patients were extracted from medical records, and glycemic metrics from CGM profiles.

Results

The study included 248 T2DM patients, of whom 72.98 % were male, with a mean age of 60.48 years and a mean HbA1c value of 8.319 %. Linear regression analysis revealed that TIR was significantly negatively associated with HbA1c values (coefficient=-6.746) and duration of diabetes (coefficient=-0.425). The body mass index (BMI) showed a positive association with TIR (coefficient=0.649; P = 0.032). For TBR, only HbA1c values showed a significant negative association (coefficient=-1.051; P = 0.009), whereas age, duration of diabetes, and BMI were not significant predictors.

Conclusion

The study highlights the significant relationships between CGM-derived metrics (TIR and TBR), and clinical parameters in Indian patients with T2DM, and their effectiveness in identifying patients at risk of inadequate glycemic control.

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印度2型糖尿病患者连续血糖监测指标与临床参数的关系

背景：评估印度2型糖尿病（T2DM）患者连续血糖监测（CGM）衍生指标（如范围内时间（TIR）和范围下时间（TBR））与临床参数之间的相关性，为CGM在该人群中的有效性提供见解。方法：这是一项使用Freestyle Libre/Libre Pro CGM系统的18岁及以上T2DM患者的单中心、回顾性观察研究。这些患者的人口学和临床数据从医疗记录中提取，血糖指标从CGM档案中提取。结果：研究纳入T2DM患者248例，其中男性72.98 %，平均年龄60.48岁，平均HbA1c值8.319 %。线性回归分析显示，TIR与HbA1c值（系数=-6.746）和糖尿病病程（系数=-0.425）呈显著负相关。体质指数（BMI）与TIR呈正相关(系数=0.649； = 0.032页)。对于TBR，只有HbA1c值呈显著负相关(系数=-1.051；P = 0.009)，而年龄、糖尿病病程和BMI不是显著的预测因子。结论：该研究强调了cgm衍生指标（TIR和TBR）与印度T2DM患者临床参数之间的显著关系，以及它们在识别血糖控制不足风险患者方面的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Primary Care Diabetes ENDOCRINOLOGY & METABOLISM-PRIMARY HEALTH CARE

CiteScore

5.00

自引率

3.40%

发文量

134

审稿时长

47 days

期刊介绍： The journal publishes original research articles and high quality reviews in the fields of clinical care, diabetes education, nutrition, health services, psychosocial research and epidemiology and other areas as far as is relevant for diabetology in a primary-care setting. The purpose of the journal is to encourage interdisciplinary research and discussion between all those who are involved in primary diabetes care on an international level. The Journal also publishes news and articles concerning the policies and activities of Primary Care Diabetes Europe and reflects the society''s aim of improving the care for people with diabetes mellitus within the primary-care setting.