Alterations of retinal microvascular density in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-06-25 DOI:10.1016/j.pdpdt.2025.104690

Kaibao Ji , Yi Zhao , Hongli Liu , Qinglin Zhang , Yang Yang , Wei Wan

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引用次数: 0

Abstract

Background

The present study aimed to evaluate retinal microvascular alterations in patients with chronic obstructive pulmonary disease (COPD) utilizing optical coherence tomography angiography (OCTA).

Methods

Pertinent articles comparing retinal vascular characteristics between eyes of COPD patients and healthy controls were systematically retrieved from PubMed, Embase, the Cochrane Library, and Web of Science from inception until June 2024. For continuous variables, mean differences with 95 % confidence intervals were calculated using Review Manager Version 5.4.

Results

A total of six eligible studies encompassing 530 eyes (279 eyes in the COPD group and 251 eyes in the control group) were included in the meta-analysis. The analysis revealed a significant reduction in macular whole enface vessel density (VD) measured by OCTA in COPD patients compared to controls, with pooled mean differences of -2.16 (P = 0.04) for superficial VD and -2.93 for deep VD (P = 0.01). Additionally, combined values for parafoveal and perifoveal deep VD measured by OCTA were significantly lower in COPD patients than those observed in normal controls (MD= -2.31, P = 0.003; MD= -3.79, P = 0.03 respectively). Furthermore, pooled results indicated that radial peripapillary capillary (RPC) whole image VD, RPC inside disc VD, and RPC peripapillary VD detected by OCTA were markedly decreased in the COPD cohort compared to controls (MD= -1.68, P < 0.0001; MD= -2.14, P = 0.003; MD= -1.86, P = 0.0002 respectively).

Conclusion

Our findings indicate that individuals with COPD exhibit reduced vessel densities both within macular regions and at the optic nerve head area, thereby suggesting that OCTA metrics can serve as a potential auxiliary tool for diagnosing COPD due to their non-invasive nature and rapid assessment capabilities, especially if confounding diseases that can also affect retinal vessel densities are considered with care.

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慢性阻塞性肺疾病患者视网膜微血管密度的改变：系统回顾和荟萃分析

背景：本研究旨在利用光学相干断层扫描血管造影（OCTA）评估慢性阻塞性肺疾病（COPD）患者的视网膜微血管改变。方法：系统检索PubMed、Embase、Cochrane图书馆和Web of Science从成立到2024年6月的相关文章，比较COPD患者和健康对照者眼睛视网膜血管特征。对于连续变量，使用Review Manager Version 5.4计算95%置信区间的平均差异。结果：荟萃分析共纳入6项符合条件的研究，涉及530只眼睛（COPD组279只眼睛，对照组251只眼睛）。分析显示，与对照组相比，慢性阻塞性肺病患者OCTA测量的黄斑全面血管密度（VD）显著降低，浅表VD的平均差异为-2.16 (P= 0.04)，深VD的平均差异为-2.93 （P= 0.01）。此外，慢性阻塞性肺病患者的OCTA测量的凹旁和凹周围深度VD的综合值显著低于正常对照组(MD= -2.31， P= 0.003；MD= -3.79， P= 0.03)。此外，合并结果显示，与对照组相比，COPD队列中径向乳头周围毛细血管（RPC）全像VD、RPC内盘VD和OCTA检测的RPC乳头周围VD均显著降低(MD= -1.68， P< 0.0001；Md = -2.14, p = 0.003；MD= -1.86， P= 0.0002)。结论：我们的研究结果表明，慢性阻塞性肺疾病患者在黄斑区域和视神经头区域均表现出血管密度降低，因此表明OCTA指标可以作为诊断慢性阻塞性肺疾病的潜在辅助工具，因为它具有非侵入性和快速评估能力，特别是如果仔细考虑可能影响视网膜血管密度的混杂疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.