The State of Single-Cell Atlas Data Visualization in the Biological Literature.

IF 1.4 4区 计算机科学 Q3 COMPUTER SCIENCE, SOFTWARE ENGINEERING
Mark S Keller, Eric Morth, Thomas C Smits, Simon Warchol, Grace Guo, Qianwen Wang, Robert Krueger, Hanspeter Pfister, Nils Gehlenborg
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引用次数: 0

Abstract

Recent advancements have enabled tissue samples to be profiled at the unprecedented level of detail of a single cell. Analysis of this data has enabled discoveries that are relevant to understanding disease and developing therapeutics. Large-scale profiling efforts are underway which aim to generate 'atlas' resources that catalog cellular archetypes including biomarkers and spatial locations. While the problem of cellular data visualization is not new, the size, resolution, and heterogeneity of single-cell atlas datasets presents challenges and opportunities. We survey the usage of visualization to interpret single-cell atlas datasets by assessing over 1,800 figure panels from 45 biological publications. We intend for this report to serve as a foundational resource for the visualization community as atlas-scale single-cell datasets are emerging rapidly with aims of advancing our understanding of biological function in health and disease.

生物学文献中单细胞图谱数据可视化的现状。
最近的进展使组织样本能够在单个细胞的细节上达到前所未有的水平。对这些数据的分析使人们能够发现与了解疾病和开发治疗方法相关的发现。大规模的分析工作正在进行中,旨在生成“图谱”资源,对细胞原型进行分类,包括生物标志物和空间位置。虽然细胞数据可视化问题并不新鲜,但单细胞图谱数据集的大小、分辨率和异质性带来了挑战和机遇。我们通过评估来自45份生物学出版物的1800多个图面板,调查了可视化解释单细胞图谱数据集的使用情况。随着atlas规模的单细胞数据集的迅速出现,我们打算将本报告作为可视化社区的基础资源,目的是促进我们对健康和疾病的生物学功能的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
IEEE Computer Graphics and Applications
IEEE Computer Graphics and Applications 工程技术-计算机:软件工程
CiteScore
3.20
自引率
5.60%
发文量
160
审稿时长
>12 weeks
期刊介绍: IEEE Computer Graphics and Applications (CG&A) bridges the theory and practice of computer graphics, visualization, virtual and augmented reality, and HCI. From specific algorithms to full system implementations, CG&A offers a unique combination of peer-reviewed feature articles and informal departments. Theme issues guest edited by leading researchers in their fields track the latest developments and trends in computer-generated graphical content, while tutorials and surveys provide a broad overview of interesting and timely topics. Regular departments further explore the core areas of graphics as well as extend into topics such as usability, education, history, and opinion. Each issue, the story of our cover focuses on creative applications of the technology by an artist or designer. Published six times a year, CG&A is indispensable reading for people working at the leading edge of computer-generated graphics technology and its applications in everything from business to the arts.
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