Strengthening Radiation Response and Expanding Cytogenetic Applications: Indian Biodosimetry Network (IN-BioDoS).

Abstract

As nuclear energy and radiation applications expand, advancing biodosimetry is crucial for assessing radiation exposure, especially during radiological emergencies. The Bhabha Atomic Research Centre's (BARC) Biodosimetry Laboratory has pioneered dose estimation techniques, including dicentric chromosome assay (DCA), cytokinesis block micronucleus assay (CBMN), Chromosomal translocation by fluorescence in situ hybridization (FISH), γH2AX, 53BP1, and premature chromosome condensation (PCC). To enhance preparedness, BARC has launched the Indian Biodosimetry Network (IN-BioDoS), integrating cytogenetic with an aim to standardize methods, promote collaboration, and ensure accurate dose assessments through inter-⁠laboratory comparisons. Future expansions, including rapid biodosimetry techniques and global partnerships, will strengthen the handling of radiation emergencies. These techniques also hold potential in clinical diagnostics, personalized medicine, and drug testing, reinforcing societal applications in medical care.