Hepatitis viruses hijack cellular metabolic pathways to drive replication and disease: Implications for novel therapeutics.

Abstract

Hepatitis viruses are one of the most common viruses threatening humans all over the world, which can lead to viral hepatitis and even increase the risk of hepatocellular carcinoma. Numerous investigations have shown that hepatitis viruses reprogram the metabolisms of infected cells, including alterations in glucose, amino acid, and lipid metabolic pathways, resulting in changes of the life cycles of viruses, the status of host cells and the development of diseases. In this review, we summarized how hepatitis viruses rewire cells' metabolisms to promote virus replication and pathogenesis, which contributes to the exploitation of potential therapeutic paradigms.