RXRG as a Novel Biomarker and its Correlation With Immune Infiltration in Thyroid Carcinoma.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-07-01 DOI:10.21873/invivo.13998

Pengzhao Song, Tianqi Chen, Pengfei Gu, Yahui Sun, Yong Han

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引用次数: 0

Abstract

Background/aim: Thyroid carcinoma (THCA) is the most prevalent type of endocrine cancer. Retinoid X Receptor Gamma (RXRG) encodes a member of the retinoid X receptor (RXR) family of nuclear receptors that are involved in mediating the antiproliferative effects of retinoic acid (RA). However, the role of RXRG in THCA remains unclear.

Materials and methods: Multiple public databases were utilized to investigate RXRG expression in THCA and its role in THCA prognosis, analyze the RXRG co-expressed genes and protein-protein interaction (PPI) networks, as well as to analyze the immune cell infiltration in THCA using enrichment analysis and the association of RXRG expression with immune cell infiltration.

Results: The expression of RXRG is higher in THCA tissues than in normal thyroid tissues. In THCA, a reduced expression of RXRG is associated with poor prognosis. Both the pathological stage and RXRG expression are independent risk factors for the overall survival (OS) of THCA patients. RXRG is mainly associated with signaling pathways such as cytokine-cytokine receptor interaction, chemokine signaling pathway, interleukin signaling, and interleukin-18 signaling pathway, all of which may be related to immunity. Finally, it was found that the expression of RXRG is associated with the infiltration of various immune cells and may affect the prognosis of patients through changes in the immune environment.

Conclusion: RXRG has a significant impact on the tumor microenvironment (TME) of THCA, potentially serving as a valuable biomarker for the diagnosis and treatment of this malignancy.

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RXRG作为新的生物标志物及其与甲状腺癌免疫浸润的关系

背景/目的：甲状腺癌（THCA）是最常见的内分泌肿瘤。类视黄酸X受体γ (RXRG)编码类视黄酸X受体（RXR）核受体家族的一个成员，参与介导维甲酸（RA）的抗增殖作用。然而，RXRG在THCA中的作用尚不清楚。材料和方法：利用多个公共数据库研究RXRG在THCA中的表达及其对THCA预后的影响，分析RXRG共表达基因和蛋白-蛋白相互作用（PPI）网络，并通过富集分析分析THCA中免疫细胞浸润情况，以及RXRG表达与免疫细胞浸润的关系。结果：RXRG在THCA组织中的表达高于正常甲状腺组织。在THCA中，RXRG的表达降低与预后不良相关。病理分期和RXRG表达均是影响THCA患者总生存期（OS）的独立危险因素。RXRG主要与细胞因子-细胞因子受体相互作用、趋化因子信号通路、白细胞介素信号通路、白细胞介素-18信号通路等信号通路相关，这些信号通路都可能与免疫有关。最后发现RXRG的表达与多种免疫细胞的浸润有关，并可能通过改变免疫环境影响患者的预后。结论：RXRG对THCA的肿瘤微环境（tumor microenvironment， TME）有显著影响，可能作为THCA诊断和治疗的有价值的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.