Ovarian Cancer and the Risk of Cataract Episodes: A Nationwide Cohort Study.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-07-01 DOI:10.21873/invivo.14026

Chia-Yi Lee, Shun-Fa Yang, Elsa Lin-Chin Mai, Yu-Ling Chang, Jing-Yang Huang, Chao-Kai Chang

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引用次数: 0

Abstract

Background/aim: The aim of this study was to explore the potential association between ovarian cancer and cataracts using the Longitudinal Health Insurance Research Database (LHIRD) of Taiwan.

Patients and methods: A retrospective cohort study was conducted, and patients with ovarian cancer were age-matched with non-ovarian cancer patients in a 1:4 ratio. A total of 4,980 and 19,920 participants were classified into the ovarian cancer and non-ovarian cancer groups, respectively. The primary outcome was the presence of cataracts and cataract surgery. Cox proportional hazard regression was used to calculate the adjusted hazard ratio (aHR) and the 95% confidence intervals (CIs) of the primary outcomes between the groups.

Results: A total of 484 and cataract events were recorded in the ovarian cancer group, while 2,383 cataract events were recorded in the non-ovarian cancer group. The ovarian cancer group had a non-significantly higher incidence of cataracts compared to the non-ovarian cancer group (aHR=1.07, 95%CI=0.97-1.19, p=0.074), and the incidences of individuals with advanced cataracts receiving surgery were statistically equal between the ovarian cancer group and the non-ovarian cancer group (aHR=0.93, 95%CI=0.79-1.10, p=0.397). In subgroup analyses, differences in cataract incidences were not significant between ovarian cancer and non-ovarian cancer subgroups with different ages or durations of ovarian cancer (all p>0.05).

Conclusion: Ovarian cancer is associated with a marginally higher incidence of cataracts and cataract surgery.

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卵巢癌和白内障发作的风险：一项全国性队列研究。

背景/目的：本研究旨在利用台湾健康保险纵向研究资料库（LHIRD），探讨卵巢癌与白内障之间的潜在关联。患者和方法：采用回顾性队列研究，卵巢癌患者与非卵巢癌患者按1:4的比例年龄匹配。共有4980名和19920名参与者分别被分为卵巢癌组和非卵巢癌组。主要结果是是否存在白内障和白内障手术。采用Cox比例风险回归计算各组间主要结局的校正风险比（aHR）和95%置信区间（CIs）。结果：卵巢癌组共记录白内障事件484例，非卵巢癌组共记录白内障事件2383例。卵巢癌组白内障的发生率较非卵巢癌组无显著性增高（aHR=1.07, 95%CI=0.97-1.19, p=0.074），晚期白内障患者接受手术的发生率在卵巢癌组与非卵巢癌组间无统计学差异（aHR=0.93, 95%CI=0.79-1.10, p=0.397）。在亚组分析中，不同年龄、不同病程的卵巢癌亚组与非卵巢癌亚组的白内障发生率差异无统计学意义（p < 0.05）。结论：卵巢癌与白内障及白内障手术的发生率有一定的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.