Clinical Significance of the Geriatric Nutritional Risk Index in the Evaluation of Outcomes of Patients After Radical Gastrectomy.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-07-01 DOI:10.21873/invivo.14023

Mie Tanabe, Toru Aoyama, Itaru Hashimoto, Yuta Nakayama, Junya Morita, Kyohei Kanematsu, Shinsuke Nagasawa, Yukio Maezawa, Takanobu Yamada, Takashi Ogata, Aya Saito, Takashi Oshima

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引用次数: 0

Abstract

Background/aim: The clinical evaluation of the GNRI in nutritional status management has been reported in several malignancies. This study aimed to investigate the relationship between the GNRI and clinical outcomes in postoperative patients who underwent radical gastrectomy.

Patients and methods: Clinical data of 940 gastric cancer patients who underwent radical gastrectomy at Kanagawa Cancer Center from 2013 to 2020 were retrospectively collected and divided into a high-GNRI group (≥98) and a low-GNRI group (<98) according to the GNRI. The association between the GNRI and overall survival (OS) and recurrence-free survival (RFS) was investigated.

Results: The respective 3- and 5-year OS rates were 92.0% and 86.3% in the high-GNRI group and 82.4% and 73.2% in the low-GNRI group (p<0.001). A multivariate analysis showed that the GNRI was an independent predictor of the OS and RFS.

Conclusion: GNRI is an objective, noninvasive, and easily accessible prognostic biomarker for gastric cancer patients. Patient stratification using the GNRI and preoperative nutritional interventions may improve prognosis.

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老年营养风险指数评价胃癌根治术后预后的临床意义。

背景/目的：GNRI在营养状况管理中的临床评价已被报道用于几种恶性肿瘤。本研究旨在探讨胃癌根治术后患者GNRI与临床预后的关系。患者和方法：回顾性收集2013 - 2020年神奈川癌症中心940例胃癌根治术患者的临床资料，分为高GNRI组（≥98）和低GNRI组（结果：高GNRI组3年和5年OS分别为92.0%和86.3%，低GNRI组82.4%和73.2%）。结论：GNRI是一种客观、无创、易于获取的胃癌患者预后生物标志物。采用GNRI进行患者分层和术前营养干预可以改善预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.