Akira Mima, Takamasa Matsuki, Takahiro Nakamoto, Yuta Saito, Takaaki Morikawa, Sakura Kure, Keishi Matsumoto, Shinji Lee
{"title":"A Case of Seronegative Lupus Nephritis Detected Incidentally by Renal Biopsy.","authors":"Akira Mima, Takamasa Matsuki, Takahiro Nakamoto, Yuta Saito, Takaaki Morikawa, Sakura Kure, Keishi Matsumoto, Shinji Lee","doi":"10.21873/invivo.14029","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aim: </strong>Systemic lupus erythematosus (SLE) and lupus nephritis (LN) are autoimmune diseases that affect multiple organ systems with the production of pathological autoantibodies.</p><p><strong>Case report: </strong>We describe the case of a 19-year-old man who had microscopic hematuria and mild proteinuria. No skin rash, joint symptoms, serositis, neuropathy, or cytopenia were observed. Renal biopsy revealed the thickness of the glomerular basement membrane, granular deposits of C1q along mesangial areas, and high electron density deposits in basement membrane on the epithelial side of the glomerulus. After operating renal biopsy, laboratory tests were performed and the results were not associated with SLE. This leads to the diagnosis of class V seronegative LN. The patient achieved remission only with angiotensin II receptor blocker without immunosuppressive drugs. There have been few reports of seronegative LN.</p><p><strong>Conclusion: </strong>Our case report presents a case of seronegative LN identified incidentally during renal biopsy.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2328-2332"},"PeriodicalIF":1.8000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223612/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"In vivo","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/invivo.14029","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background/aim: Systemic lupus erythematosus (SLE) and lupus nephritis (LN) are autoimmune diseases that affect multiple organ systems with the production of pathological autoantibodies.
Case report: We describe the case of a 19-year-old man who had microscopic hematuria and mild proteinuria. No skin rash, joint symptoms, serositis, neuropathy, or cytopenia were observed. Renal biopsy revealed the thickness of the glomerular basement membrane, granular deposits of C1q along mesangial areas, and high electron density deposits in basement membrane on the epithelial side of the glomerulus. After operating renal biopsy, laboratory tests were performed and the results were not associated with SLE. This leads to the diagnosis of class V seronegative LN. The patient achieved remission only with angiotensin II receptor blocker without immunosuppressive drugs. There have been few reports of seronegative LN.
Conclusion: Our case report presents a case of seronegative LN identified incidentally during renal biopsy.
期刊介绍:
IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management.
The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.