A Case of Seronegative Lupus Nephritis Detected Incidentally by Renal Biopsy.

IF 1.8 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
In vivo Pub Date : 2025-07-01 DOI:10.21873/invivo.14029
Akira Mima, Takamasa Matsuki, Takahiro Nakamoto, Yuta Saito, Takaaki Morikawa, Sakura Kure, Keishi Matsumoto, Shinji Lee
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引用次数: 0

Abstract

Background/aim: Systemic lupus erythematosus (SLE) and lupus nephritis (LN) are autoimmune diseases that affect multiple organ systems with the production of pathological autoantibodies.

Case report: We describe the case of a 19-year-old man who had microscopic hematuria and mild proteinuria. No skin rash, joint symptoms, serositis, neuropathy, or cytopenia were observed. Renal biopsy revealed the thickness of the glomerular basement membrane, granular deposits of C1q along mesangial areas, and high electron density deposits in basement membrane on the epithelial side of the glomerulus. After operating renal biopsy, laboratory tests were performed and the results were not associated with SLE. This leads to the diagnosis of class V seronegative LN. The patient achieved remission only with angiotensin II receptor blocker without immunosuppressive drugs. There have been few reports of seronegative LN.

Conclusion: Our case report presents a case of seronegative LN identified incidentally during renal biopsy.

肾活检偶然发现血清阴性狼疮性肾炎1例。
背景/目的:系统性红斑狼疮(SLE)和狼疮肾炎(LN)是通过产生病理性自身抗体影响多器官系统的自身免疫性疾病。病例报告:我们描述了一个19岁的男子谁显微镜下血尿和轻度蛋白尿。未见皮疹、关节症状、浆液炎、神经病变或细胞减少。肾活检显示肾小球基底膜增厚,沿系膜区可见C1q颗粒状沉积,肾小球上皮侧基底膜可见高密度电子沉积。手术肾活检后,进行了实验室检查,结果与SLE无关。这导致诊断为V级血清阴性LN。患者仅使用血管紧张素受体阻滞剂而不使用免疫抑制药物获得缓解。很少有血清阴性LN的报道。结论:我们的病例报告提出了一个病例血清阴性LN偶然发现肾活检。
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来源期刊
In vivo
In vivo 医学-医学:研究与实验
CiteScore
4.20
自引率
4.30%
发文量
330
审稿时长
3-8 weeks
期刊介绍: IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.
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