Frequency and Risk Factors of Inappropriate Bladder Filling in Patients Irradiated for High-risk Prostate Cancer.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-07-01 DOI:10.21873/invivo.14030

Dirk Rades, Laura Doehring, Jan-Dirk Küter, Justus Domschikowski, Jon Cacicedo, Stefan Janssen

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引用次数: 0

Abstract

Background/aim: Many patients with high-risk prostate cancer receive normo-fractionated irradiation. Previously, high-risk cancer and pre-treatment bladder volumes <200 ml were associated with inappropriate bladder filling during the radiotherapy course. A prospective trial will investigate the value of an app reminding patients to drink water before each radiotherapy session. This study provides information regarding magnitude of inappropriate bladder filling and risk factors required for the prospective trial.

Patients and methods: In 23 patients with high-risk prostate cancer and inappropriate pre-treatment bladder filling, mean and median numbers of radiation fractions with bladder volumes less than 200 ml and potential risk factors were retrospectively investigated.

Results: Mean and median numbers of fractions with volumes less than 200 ml were 29.2±6.6 and 32.0 (interquartile range=24.0-35.0) of 35 fractions. Higher numbers were significantly associated with a lower performance score (p <0.029).

Conclusion: Bladder filling was inappropriate during most radiotherapy fractions and, therefore, must be considered a significant problem. Our results are relevant for a subsequent prospective trial.

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高危前列腺癌放疗患者膀胱不适当充盈的频率及危险因素。

背景/目的：许多高危前列腺癌患者接受正常分次放疗。既往高危癌及术前膀胱容量患者及方法：回顾性分析23例高危前列腺癌术前膀胱填充不当患者，膀胱容量小于200ml的放射分数的平均值和中位数及潜在危险因素。结果：35个馏分中体积小于200 ml的馏分平均为29.2±6.6个，中位数为32.0个（四分位数间距为24.0 ~ 35.0）。结论：膀胱充盈在大多数放射治疗中是不合适的，因此必须被认为是一个重大问题。我们的结果与随后的前瞻性试验相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.