Development and evaluation of a quality-of-life questionnaire for patients with orbital malignant tumours.

IF 2 Q2 OPHTHALMOLOGY

BMJ Open Ophthalmology Pub Date : 2025-06-26 DOI:10.1136/bmjophth-2024-001842

Haihan Yan, Junlian Lang, Shaoxiao Yan, Li Wang, Rui Liu, Nan Wang, Liangyuan Xu, Qihan Guo, Tingting Ren, Runzi Yang, Yufei Zhang, Feng Ke, Jianmin Ma

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Abstract

Background: Orbital malignant tumours seriously affect the quality of life of patients; however, there is currently no quality-of-life questionnaire for patients with orbital malignant tumours.

Objective: To develop and evaluate a quality-of-life questionnaire for patients with orbital malignant tumours.

Methods: A pool of items was generated through a literature search, expert meeting and patient interview. Pre-survey and scale evaluation were performed, the quality-of-life questionnaire for patients with orbital malignant tumours (QLQ-OT) was modified, and the scale was evaluated by measuring the quality of life of 46 patients with orbital tumours.

Results: The effective rate of QLQ-OT was 97.4%, the Cronbach's alpha coefficient was >0.6, and the test-retest reliability Intraclass Correlation Coefficient was >0.7, suggesting good internal consistency and test-retest reliability. The Pearson correlation coefficients were >0.8 between individual domain scores; > 0.6 between items and their own domains in the QLQ-OT; and >0.6 between domains and their corresponding domains in Quality of Life Center Questionnaire, thereby indicating good content, convergent and criterion-related validity. Ten principal components (the initial eigenvalues >1) were abstracted from 38 items of the general by factor analysis, accounting for 81.0% of cumulative variance.

Conclusions: QLQ-OT has good compliance, reliability, validity and responsiveness and can be used to measure the quality of life of patients with orbital malignant tumours.

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眼眶恶性肿瘤患者生活质量问卷的制定与评价。

背景：眼眶恶性肿瘤严重影响患者的生活质量；然而，目前尚无针对眼眶恶性肿瘤患者的生活质量调查问卷。目的：编制并评价眼眶恶性肿瘤患者的生活质量问卷。方法：通过文献检索、专家会议和患者访谈等方式生成项目库。进行预调查和量表评定，修改眼窝恶性肿瘤患者生活质量问卷（QLQ-OT），通过测量46例眼窝恶性肿瘤患者的生活质量对量表进行评定。结果：QLQ-OT的有效率为97.4%,Cronbach’s alpha系数为>0.6，重测信度类内相关系数为>0.7，具有良好的内部一致性和重测信度。各领域得分之间的Pearson相关系数为bb0 0.8；在QLQ-OT中，项目和它们自己的域之间的> 0.6；在生活质量中心问卷中，域与相应域之间的差异为>0.6，表明内容、收敛性和标度相关的效度较好。通过因子分析，从38个一般性条目中提取了10个主成分（初始特征值>1），占累积方差的81.0%。结论：QLQ-OT具有良好的依从性、信度、效度和反应性，可用于衡量眼眶恶性肿瘤患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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