Recent synthetic strategies for N-arylation of piperidine using metal catalysts: A potential template for biologically active molecules

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-04-09 DOI:10.1080/00397911.2025.2490575

Farah Yasmeen (Data curation Formal analysis Investigation Writing – original draft) , Matloob Ahmad (Conceptualization Project administration Supervision Visualization Writing – original draft Writing – review & editing) , Sana Aslam (Conceptualization Data curation Formal analysis Investigation Writing – review & editing) , Muhammad Zubair (Conceptualization Formal analysis Writing – original draft) , Syed Ali Raza Naqvi (Formal analysis Investigation Methodology Resources Writing – review & editing)

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引用次数: 0

Abstract

N-Arylpiperidine is an essential scaffold of various pharmaceuticals, agrochemicals, and other organic substances. This moiety is an integral part of the structure of a variety of drugs. It demonstrates an extensive scope of biological applications, including antibiotic, anticancer, antifungal, anti-inflammatory, antihypertensive, analgesic, and antipsychotic activities. Numerous transition metal catalysts are used for the N-arylation of piperidine via coupling reactions. Ullmann and Buchwald-Hartwig coupling reactions are the most commonly used methods to link the piperidine moiety with the aryl group via C-N bond formation. Multicomponent, microwave-mediated, condensation, cyclization, addition, and metal-free reactions are also employed for the N-arylation of piperidine. This review presents different routes for N-arylation of piperidine reported in 2019–2024.

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利用金属催化剂合成哌啶n -芳基化的新策略：一种潜在的生物活性分子模板

n -芳基哌啶是各种药物、农用化学品和其他有机物质的基本支架。这部分是多种药物结构的组成部分。它具有广泛的生物学应用，包括抗生素、抗癌、抗真菌、抗炎、降压、镇痛和抗精神病活性。许多过渡金属催化剂被用于通过偶联反应实现哌啶的n -芳基化。Ullmann和Buchwald-Hartwig偶联反应是最常用的通过C-N键形成将哌啶部分与芳基连接的方法。多组分、微波介导、缩合、环化、加成和无金属反应也可用于哌啶的n -芳基化。本文综述了2019-2024年报道的哌啶n -芳基化的不同途径。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.