An efficient one pot synthesis of 6-(benzyloxy)-5-(2-(2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl)thiazol-4-yl)quinolin-2(1H)-ones

IF 1.4 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2025-06-03 DOI:10.1080/10426507.2025.2507021

Manohar D. Suryawanshi (Conceptualization Resources Writing – original draft Writing – review & editing) , Nitin M. Thorat (Methodology) , Vilas A. Sudrik (Investigation) , Ganesh D. Suryawanshi (Conceptualization Methodology) , Pravin C. Mhaske (Project administration Supervision) , Shamrao P. Lawande (Supervision)

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Abstract

Synthesis of multiheterocyclic compounds enhances the bioactivity of core moieties. The number of heteroatoms present in the molecule provides good binding nature as well as lyophilic nature. New and efficient method has been developed for one-pot synthesis of 6-(benzyloxy)-5-(2-(2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl)-thiazol-4-yl)quinolin-2(1H)-one derivatives. The reaction between 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde and thiosemicarbazide followed by cyclocondensation reaction with 6-benzyloxy-5-(2-bromo-acetyl)-1H-quinolin-2-one in ethanol under microwave or ultra-sonication condition affords the desired compounds. The described method of synthesis is time saving and contains efficient protocols.

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一锅高效合成6-（苯氧基）-5-（2-（2-（（3-芳基-1-苯基-1H-吡唑-4-基）亚甲基）肼基）噻唑-4-基）喹啉-2(1H)-酮

多杂环化合物的合成提高了核心部分的生物活性。分子中存在的杂原子数量提供了良好的结合性和亲水性。建立了一锅法合成6-（苯氧基）-5-(2-（2-（（3-芳基-1-苯基-1H-吡唑-4-基）亚甲基）肼基-噻唑-4-基）喹啉-2(1H)- 1衍生物的新方法。通过3-芳基-1-苯基- 1h -吡唑-4-乙醛与硫代氨基脲的反应，再与6-苄基-5-（2-溴乙酰基）- 1h -喹啉-2- 1在乙醇中进行微波或超声波条件下的环缩合反应，得到所需的化合物。所描述的合成方法节省时间，包含有效的协议。

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来源期刊

Phosphorus, Sulfur, and Silicon and the Related Elements 化学-无机化学与核化学

CiteScore

2.60

自引率

7.70%

发文量

103

审稿时长

2.1 months

期刊介绍： Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.