{"title":"Primary cutaneous lymphoma is a microsatellite stable tumor: An analysis of microsatellite instability.","authors":"Saki Maeda-Otsuka, Myangat Tselmeg Mijiddorj, Ikko Kajihara, Soichiro Sawamura, Katsunari Makino, Shinichi Masuguchi, Satoshi Fukushima","doi":"10.5582/ddt.2025.01042","DOIUrl":null,"url":null,"abstract":"<p><p>A deficiency in DNA mismatch repair (MMR) leads to microsatellite instability (MSI), which is associated with a favorable response to immune checkpoint inhibitors (ICIs), and the Promega MSI Analysis System is approved as a companion diagnostic tool for it. In this study, we investigated the MMR status in patients with primary cutaneous lymphoma (PCL) diagnosed at our hospital. MSI was found in 1 of the 29 patients (3.4%), an 87-year-old man diagnosed with subcutaneous panniculitis-like T-cell lymphoma. Only the NR-21 marker was present in both tumor and normal tissue, indicating that the MMR status was MSI-low, and he had a germline mutation of SLC7A8. Our study showed that most PCLs are microsatellite stable tumors. This study is a single-center small-sample investigation and requires validation in larger cohorts.</p>","PeriodicalId":520606,"journal":{"name":"Drug discoveries & therapeutics","volume":" ","pages":"212-213"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discoveries & therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5582/ddt.2025.01042","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/25 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A deficiency in DNA mismatch repair (MMR) leads to microsatellite instability (MSI), which is associated with a favorable response to immune checkpoint inhibitors (ICIs), and the Promega MSI Analysis System is approved as a companion diagnostic tool for it. In this study, we investigated the MMR status in patients with primary cutaneous lymphoma (PCL) diagnosed at our hospital. MSI was found in 1 of the 29 patients (3.4%), an 87-year-old man diagnosed with subcutaneous panniculitis-like T-cell lymphoma. Only the NR-21 marker was present in both tumor and normal tissue, indicating that the MMR status was MSI-low, and he had a germline mutation of SLC7A8. Our study showed that most PCLs are microsatellite stable tumors. This study is a single-center small-sample investigation and requires validation in larger cohorts.
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