Influence of taste and smell perception on weight loss induced by sleeve gastrectomy and its association with gut microbiota.

IF 3.8
Carolina Gutiérrez-Repiso, B Vanessa Díaz-González, María José García-López, Jacqueline Álvarez-Pérez, Lourdes Garrido-Sánchez, Isabel Moreno-Indias, Inmaculada Bautista-Castaño, Lluis Serra-Majem, Francisco J Tinahones
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Abstract

Background: Eating behavior has been suggested to be influenced by the interplay between chemosensory perception and gut microbiota. Although both factors have been suggested to be altered in obesity and modified by bariatric surgery, there is little evidence about the influence of preoperative smell and taste perception on weight loss outcomes following bariatric surgery, as well as their association with gut microbiota.

Objectives: To assess the predictive role of smell and taste perception in weight loss trajectory after sleeve gastrectomy.

Setting: Vithas Santa Catalina Hospital in Las Palmas, Spain.

Methods: This study included 35 patients who underwent sleeve gastrectomy. Smell and taste assessments and gut microbiota composition analysis were performed before bariatric surgery and 18 months postsurgery. Patients were classified according to the 50th percentile (50P) of the total taste score and olfactory Threshold-Discrimination-Identification (TDI) score.

Results: Patients with TDI>50P showed significantly higher percentage of excess weight loss (%EWL) (P = .035) and their gut microbiota was enriched in Flavonifractor, Ruminococcaceae (genus Incertae Sedis), Eggerthella, Sellimonas, and GCA-900,066,575, whilst patients with TDI<50P showed an enrichment in Eubacterium ruminantium group and Lachnospiraceae UCG-001. %EWL was significantly higher in patients with total taste score >50P (P = .049) and their microbiota were enriched in Sutterellaceae, Barnesiellaceae, Roseburia, Lachnospiraceae_UCG-004, Bilophila, Bilophila wadsworthia, Monoglobaceae and Monoglobus, whilst patients with total taste score <50P showed an enrichment in Lactobacillaceae, Lactobacillus, Klebsiella, Klebsiella pneumoniae, and Streptococcus parasanguinis.

Conclusions: Chemosensory perception could play a role in weight loss trajectory after sleeve gastrectomy through the microbiota-gut-brain axis.

味觉和嗅觉对袖式胃切除术后体重减轻的影响及其与肠道菌群的关系。
背景:进食行为被认为受化学感觉知觉和肠道微生物群之间的相互作用影响。虽然这两个因素都被认为在肥胖和减肥手术中被改变,但很少有证据表明术前嗅觉和味觉感知对减肥手术后减肥结果的影响,以及它们与肠道微生物群的关系。目的:探讨嗅觉和味觉知觉在袖胃切除术后体重减轻过程中的预测作用。地点:西班牙拉斯帕尔马斯的Vithas Santa Catalina医院。方法:本研究纳入35例行袖式胃切除术的患者。在减肥手术前和手术后18个月进行嗅觉和味觉评估以及肠道微生物群组成分析。根据总味觉评分第50百分位(50P)和嗅觉阈值-鉴别-识别(TDI)评分对患者进行分类。结果:TDI患者体重减轻率(%EWL)显著高于TDI患者(P = 0.035),其肠道菌群富集于黄酮酮、Ruminococcaceae (Incertae Sedis属)、Eggerthella、Sellimonas和GCA-900,066,575,而TDI50P患者(P = 0.049)及其肠道菌群富集于Sutterellaceae、Barnesiellaceae、Roseburia、Lachnospiraceae_UCG-004、Bilophila、Bilophila wadsworthia、monglobaceae和monglobus。结论:化学感觉知觉可能通过微生物-肠-脑轴参与袖胃切除术后的减重轨迹。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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