Reactivation fails to offer the improvement sleep does.

Murray M Barsky, Alexandra Morgan, Robert Stickgold
{"title":"Reactivation fails to offer the improvement sleep does.","authors":"Murray M Barsky, Alexandra Morgan, Robert Stickgold","doi":"10.1093/sleepadvances/zpaf035","DOIUrl":null,"url":null,"abstract":"<p><p>In a dynamic process that ultimately affords memories their persistence, memory reconsolidation can serve to strengthen associations following reactivation, particularly in sleep, where active processes may effect overnight enhancement. Reactivation can also occur in wake, where improvement would be unexpected. In an earlier study using performance on the Weather Prediction Task (WPT) as a measure of probabilistic category learning, we looked at the effect of sleep and found significant improvement after a daytime nap, where improvement correlated with the amount of REM sleep obtained. When we introduced interference training following sleep, this REM sleep benefit vanished: post-learning task memory was otherwise preserved. Here, we follow up on these results and test whether reactivation itself-wake reactivation-might be sufficient to induce the improvement found after REM sleep. Our results show that it is not: we saw no improvement on the WPT following reactivation in wake, suggesting sleep may be unique in supporting memory improvement. When we looked at interference effects, we saw unexplained differences between wake and sleep that suggest that while interference is uniformly destabilizing of WPT memories during wake, interference after REM show effects on the memory trace formed during initial learning that are distinctly different from its effects on the subsequently sleep-enhanced memory.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf035"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199604/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep advances : a journal of the Sleep Research Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/sleepadvances/zpaf035","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

In a dynamic process that ultimately affords memories their persistence, memory reconsolidation can serve to strengthen associations following reactivation, particularly in sleep, where active processes may effect overnight enhancement. Reactivation can also occur in wake, where improvement would be unexpected. In an earlier study using performance on the Weather Prediction Task (WPT) as a measure of probabilistic category learning, we looked at the effect of sleep and found significant improvement after a daytime nap, where improvement correlated with the amount of REM sleep obtained. When we introduced interference training following sleep, this REM sleep benefit vanished: post-learning task memory was otherwise preserved. Here, we follow up on these results and test whether reactivation itself-wake reactivation-might be sufficient to induce the improvement found after REM sleep. Our results show that it is not: we saw no improvement on the WPT following reactivation in wake, suggesting sleep may be unique in supporting memory improvement. When we looked at interference effects, we saw unexplained differences between wake and sleep that suggest that while interference is uniformly destabilizing of WPT memories during wake, interference after REM show effects on the memory trace formed during initial learning that are distinctly different from its effects on the subsequently sleep-enhanced memory.

再激活无法提供睡眠所能提供的改善。
在一个最终使记忆持久的动态过程中,记忆再巩固可以在再激活后加强联想,特别是在睡眠中,活跃的过程可能会在夜间增强。重新激活也可能发生在尾流中,此时的改善是意料之外的。在早期的一项研究中,我们使用天气预测任务(WPT)的表现作为概率类别学习的衡量标准,研究了睡眠的影响,发现白天小睡后显著改善,其中改善与获得的快速眼动睡眠的时间有关。当我们在睡眠后引入干扰训练时,这种快速眼动睡眠的好处消失了:学习后的任务记忆在其他方面得到了保留。在这里,我们继续研究这些结果,并测试再激活本身——清醒再激活——是否足以诱导快速眼动睡眠后的改善。我们的研究结果表明,事实并非如此:我们发现醒着时WPT在重新激活后没有任何改善,这表明睡眠可能在支持记忆改善方面是独一无二的。当我们观察干扰效应时,我们发现了清醒和睡眠之间无法解释的差异,这表明,虽然干扰在清醒期间一致破坏WPT记忆的稳定,但REM后的干扰对最初学习过程中形成的记忆痕迹的影响与对随后睡眠增强记忆的影响截然不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.10
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信