Examining rhabdomyolysis-related acute kidney injury in COVID-19 patients and its comparison to other acute kidney injury types.

Liyan Ajit D Souza, Abdulqadir J Nashwan
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Abstract

Rhabdomyolysis (RM) is characterized by disrupting muscle cells and releasing intracellular components into circulation. Some symptoms associated with RM include muscle weakness, discolored urine, and myalgia. RM can be caused by coronavirus disease 2019 (COVID-19) causing exaggerated immune response leading to muscle damage. Acute kidney injury (AKI), when presented with RM, leads to increased mortality. Examining RM-related AKI and its comparison to other AKI types in COVID-19 patients could improve the management of viral infections developing RM and AKI. RM potentially complicated COVID-19 infection course and is a major etiology of AKI. RM-related AKI had higher severity and mortality than other AKI types, with increased hypercoagulopathy and inflammatory markers. Findings also express procalcitonin use in follow-ups with severe COVID-19 patients. Study limitations include small sample size, absence of kidney biopsies, and focus on the first wave of the pandemic, which should be addressed in future research to generate accurate and relevant findings.

COVID-19患者横纹肌溶解相关性急性肾损伤的检测及其与其他急性肾损伤类型的比较
横纹肌溶解(RM)的特征是破坏肌肉细胞并将细胞内成分释放到循环中。与RM相关的一些症状包括肌肉无力、尿液变色和肌痛。RM可能是由2019冠状病毒病(COVID-19)引起的过度免疫反应导致肌肉损伤引起的。急性肾损伤(AKI),当出现RM时,导致死亡率增加。在COVID-19患者中检测RM相关AKI及其与其他类型AKI的比较,可以改善病毒感染发展为RM和AKI的管理。RM可能使COVID-19感染过程复杂化,是AKI的主要病因。rm相关性AKI的严重程度和死亡率高于其他AKI类型,伴有高凝血病和炎症标志物的增加。研究结果还表明在重症COVID-19患者随访中使用降钙素原。研究的局限性包括样本量小,缺乏肾脏活检,以及关注大流行的第一波,这些应在未来的研究中加以解决,以产生准确和相关的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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