Incidence trends and disparities in infection-related malignancies of the liver among US adults, 2000-2019.

IF 4.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterology Report Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI:10.1093/gastro/goaf050

Zhihui Zou, Xue Wang, Bing Huang, Haoting Shi, Kun Yin, Tianying Fu, Zheshen Han

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Abstract

Background: Trend analysis in infection-related malignancy of the liver is still limited. We aimed to evaluate the incidence trend in hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CCA), and primary hepatic lymphoma (PHL) in the USA during 2000-2019.

Method: In this population-level study, cases of HCC, iCCA, cHCC-CCA, and PHL from the Surveillance, Epidemiology, and End Results (SEER) registries during 2000-2019 were included. The average annual percentage change (AAPC) in 2000-2019 was computed to describe the age-adjusted incidence trends for each disease and was stratified by demographic and geographic variables.

Results: HCC and iCCA incidence increased from 5.51 (per 100,000 persons) to 8.83 and 0.92 to 1.94 during 2000-2019, respectively, whereas cHCC-CCA and PHL incidence plateaued at ∼0.04 and ∼0.10, respectively. The AAPCs of HCC, iCCA, cHCC-CCA, and PHL were 2.5% (95% confidence interval [CI], 2.2% to 2.8%), 3.9% (95% CI, 2.1% to 5.7%), 0.4% (95% CI, -1.1% to 1.9%), and 0.2% (95% CI, -0.9% to 1.3%), respectively. The HCC incidence patterns differed between age groups, with a decreased trend for young adults (AAPC, -1.1% [95% CI, -2.2% to -0.1%]) and the fastest increase trend for elderly people (AAPC, 3.2% [95% CI, 2.8%-3.5%]). For iCCA, the incidence significantly increased for all age and race/ethnicity subgroups. The incidence trends in cHCC-CCA and PHL plateaued for the general population and all subgroups. Geographic disparities were found for HCC, with the highest proportion in Alaska Natives (91.6%) and the lowest proportion in Iowa (77.5%).

Conclusions: Although the incidence of infection-related malignancies of the liver increased in the USA during 2000-2019, a plateaued trend was observed for HCC during 2010-2019, especially for young adults. Racial/ethnic differences and geographic diversity remain. Systematic screening and prevention are highly requested.

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2000-2019年美国成年人肝脏感染相关恶性肿瘤的发病率趋势和差异

背景：肝脏感染相关恶性肿瘤的趋势分析仍然有限。我们旨在评估2000-2019年美国肝细胞癌（HCC）、肝内胆管癌（iCCA）、肝细胞癌和胆管癌合并（cHCC-CCA）和原发性肝淋巴瘤（PHL）的发病率趋势。方法：在这项人群水平的研究中，纳入了2000-2019年监测、流行病学和最终结果（SEER）登记处的HCC、iCCA、cHCC-CCA和PHL病例。计算2000-2019年的平均年百分比变化（AAPC），以描述每种疾病的年龄调整发病率趋势，并按人口统计学和地理变量进行分层。结果：在2000-2019年期间，HCC和iCCA的发病率分别从5.51（每10万人）增加到8.83和0.92增加到1.94，而cHCC-CCA和PHL的发病率分别稳定在0.04和0.10。HCC、iCCA、cHCC-CCA和PHL的AAPCs分别为2.5%（95%可信区间[CI]， 2.2%至2.8%）、3.9% （95% CI， 2.1%至5.7%）、0.4% （95% CI, -1.1%至1.9%）和0.2% （95% CI, -0.9%至1.3%）。不同年龄组的HCC发病率模式不同，年轻人的发病率呈下降趋势（AAPC, -1.1% [95% CI, -2.2%至-0.1%]），老年人的发病率增长趋势最快（AAPC, 3.2% [95% CI, 2.8%-3.5%]）。对于iCCA，所有年龄和种族/民族亚组的发病率均显著增加。在一般人群和所有亚组中，cHCC-CCA和PHL的发病率趋势趋于稳定。HCC存在地域差异，阿拉斯加原住民的比例最高（91.6%），爱荷华州的比例最低（77.5%）。结论：尽管在2000-2019年期间，美国肝脏感染相关恶性肿瘤的发病率有所增加，但在2010-2019年期间，HCC的发病率呈稳定趋势，尤其是在年轻人中。种族/民族差异和地理多样性依然存在。迫切需要系统的筛查和预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology Report Medicine-Gastroenterology

CiteScore

4.60

自引率

2.80%

发文量

审稿时长

8 weeks

期刊介绍： Gastroenterology Report is an international fully open access (OA) online only journal, covering all areas related to gastrointestinal sciences, including studies of the alimentary tract, liver, biliary, pancreas, enteral nutrition and related fields. The journal aims to publish high quality research articles on both basic and clinical gastroenterology, authoritative reviews that bring together new advances in the field, as well as commentaries and highlight pieces that provide expert analysis of topical issues.