[Inflammaging and metabolic syndrome: molecular mechanisms.]

Abstract

One of the most pressing medical and social problems in the world is the widespread prevalence of chronic age-associated pathology, which includes metabolic syndrome. Metabolic inflammation accompanying metabolic diseases and aging have a common pathogenesis, the basis of which is the activation of the innate immune system and an increase in the inflammatory background. During the aging process, chronic, asymptomatic, sluggish inflammation develops, called inflamaging, which leads to a cascade of pathological changes that disrupt the functions of adipose tissue and the endocrine system, and thereby contributes to the development of a number of diseases. Inflamaging is supported by various stimuli, including pathogens, endogenous cellular debris and defective molecules, as well as excess nutrients. The review examines the common mechanisms of inflammation, aging and metabolic homeostasis disorders, emphasizing the significant role of inflammaging in the development of metabolic syndrome, as well as biomarkers of age-associated diseases, the use of which as targets for therapeutic treatment can help in the fight against metabolic syndrome.