Prevalence of Vaccine-Covered and Non-Covered HPV Genotypes Among Unvaccinated Women in Ankara: A Single-Center Study.

IF 5.2 3区 医学 Q1 IMMUNOLOGY
Vaccines Pub Date : 2025-06-13 DOI:10.3390/vaccines13060640
Ayfer Bakır, Mehmet Alican Sapmaz
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引用次数: 0

Abstract

Background/objectives: Understanding the regional distribution of human papillomavirus (HPV) genotypes is essential for guiding effective vaccination and screening strategies. This study aimed to assess the prevalence and distribution of HPV genotypes among unvaccinated women aged 30 years and older undergoing routine screening in Ankara. It also aimed to compare the frequencies of genotypes included and not included in current vaccines and to investigate their association with cervical smear cytology.

Methods: This descriptive, cross-sectional, single-center study was conducted at Ankara Etlik City Hospital between 15 November 2024 and 15 February 2025. A total of 500 sexually active, unvaccinated women aged 30 years or older were enrolled. Cervical swab samples were analyzed for HPV DNA and genotypes using real-time PCR (28-type panel), and cytology results were retrospectively obtained from medical records.

Results: HPV infection was detected in 18.2% of participants. Among HPV-positive women, 71.4% had single-type and 28.6% had multiple-type infections. The most common high-risk genotypes among HPV-positive individuals were HPV 16 (13.2%), HPV 18 (13.2%), and HPV 59 (13.2%). While 35.2% of HPV-positive cases included genotypes covered by the nonavalent vaccine, 64.8% involved at least one genotype not covered, mainly HPV 59, 44, and 51. HPV was detected in 17% of individuals with normal cytology, 19% of those with atypical squamous cells of undetermined significance (ASC-US), and 100% of cases with low-grade squamous intraepithelial lesion (LSIL) (p < 0.001).

Conclusions: The findings emphasize the persistence of high-risk and non-vaccine-covered HPV types in the population, highlighting the need for updated vaccination policies and the development of broader-spectrum vaccines aligned with local genotype profiles.

安卡拉未接种疫苗妇女中接种疫苗和未接种HPV基因型的患病率:一项单中心研究
背景/目的:了解人乳头瘤病毒(HPV)基因型的区域分布对指导有效的疫苗接种和筛查策略至关重要。本研究旨在评估在安卡拉接受常规筛查的30岁及以上未接种疫苗的妇女中HPV基因型的患病率和分布。它还旨在比较目前疫苗中包括和不包括的基因型的频率,并调查它们与宫颈涂片细胞学的关系。方法:这项描述性、横断面、单中心研究于2024年11月15日至2025年2月15日在安卡拉Etlik市医院进行。总共招募了500名30岁或以上的性活跃、未接种疫苗的妇女。使用实时PCR(28型面板)分析宫颈拭子样本的HPV DNA和基因型,并从医疗记录中回顾性获得细胞学结果。结果:18.2%的参与者检测到HPV感染。在hpv阳性妇女中,71.4%为单型感染,28.6%为多型感染。HPV阳性个体中最常见的高危基因型是HPV 16(13.2%)、HPV 18(13.2%)和HPV 59(13.2%)。35.2%的HPV阳性病例包括非价疫苗覆盖的基因型,64.8%的病例包括至少一种未覆盖的基因型,主要是HPV 59、44和51。17%的细胞学正常患者、19%的非典型鳞状细胞未确定意义(ASC-US)患者和100%的低级别鳞状上皮内病变(LSIL)患者检测到HPV (p < 0.001)。结论:研究结果强调高危和未疫苗覆盖的HPV类型在人群中持续存在,强调需要更新疫苗接种政策和开发符合当地基因型谱的广谱疫苗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Vaccines
Vaccines Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
8.90
自引率
16.70%
发文量
1853
审稿时长
18.06 days
期刊介绍: Vaccines (ISSN 2076-393X) is an international, peer-reviewed open access journal focused on laboratory and clinical vaccine research, utilization and immunization. Vaccines publishes high quality reviews, regular research papers, communications and case reports.
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