Enhancing sulfasalazine solubility in supercritical carbon dioxide with ethanol cosolvent: a comprehensive study.

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-06-26 DOI:10.1038/s41598-025-04232-9

Hadil Faris Alotaibi, Suleiman Ibrahim Mohammad, Asokan Vasudevan, Suranjana V Mayani, Suhas Ballal, Munthar Kadhim Abosaoda, Abhayveer Singh, Subhashree Ray, Atreyi Pramanik

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Abstract

In this study, the solubility of sulfasalazine in supercritical carbon dioxide, using ethanol as a cosolvent, was evaluated at temperatures of 308, 318, 328, and 338 K, and at pressures reaching up to 30 MPa. A comprehensive examination was conducted to ascertain the impact of temperature, pressure, and cosolvent concentration on solubility and density. To this end, SRK as an equation of state and a range of semi-empirical correlations were employed to correlate the solubility. The Soltani-Mazloumi and Madras et al. models were identified as the most suitable model for the experimental data. The mole fraction of sulfasalazine ranged from 0.273 × 10^-4 to 1.654 × 10^-4 in the binary system, and from 1.535 × 10^-4 to 5.211 × 10^-4 and 3.263 × 10^-4 to 11.451 × 10^-4 at concentrations of 1 and 3 mol%, respectively. The findings indicated that the incorporation of a cosolvent, notably ethanol, led to a substantial enhancement in solubility. The sulfasalazine-ethanol-CO₂ system demonstrated the highest solubility at 12 MPa and 338 K, exhibiting approximately 11.95 times greater solubility compared to that observed in pure supercritical CO₂.

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乙醇助溶剂提高磺胺氮嗪在超临界二氧化碳中的溶解度的综合研究。

在本研究中，以乙醇为助溶剂，在308、318、328和338 K的温度和高达30 MPa的压力下，对磺胺嘧啶在超临界二氧化碳中的溶解度进行了评估。进行了全面的检查，以确定温度，压力和共溶剂浓度对溶解度和密度的影响。为此，SRK作为状态方程和一系列半经验相关性被用来关联溶解度。Soltani-Mazloumi和Madras等人的模型被认为是最适合实验数据的模型。在二元体系中，磺胺嘧啶的摩尔分数为0.273 × 10-4 ~ 1.654 × 10-4，在浓度为1和3 mol%时，分别为1.535 × 10-4 ~ 5.211 × 10-4和3.263 × 10-4 ~ 11.451 × 10-4。研究结果表明，助溶剂，特别是乙醇的掺入，导致溶解度的显著提高。磺胺嘧啶-乙醇-CO2体系在12 MPa和338 K下的溶解度最高，比在纯超临界CO2中观察到的溶解度高11.95倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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