Genome characterization of Trichophyton mentagrophytes genotype VII strain PG12DES from Italy.

IF 2.3 3区医学 Q3 INFECTIOUS DISEASES

Medical mycology Pub Date : 2025-06-05 DOI:10.1093/mmy/myaf054

Luca Rossi, Annarita Sorrentino, Prof Caterina Signoretto, Paolo Gaibani

引用次数: 0

Abstract

We characterized the genome of the clinical Trichophyton mentagrophytes genotype VII strain PG12DES. PG12DES genome harbored different virulence factors, including MEP-1, MEP-2, MEP-3, MEP-4, SUB-6, and ZAF-A. Phylogenetic analysis revealed that PG12DES was clonally related to a T. mentagrophytes strain isolated in Moldova in 2017. This study provides the genome characterization of a clinical strain from Italy and broadens the knowledge of the emergent genotype VII.

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意大利墨农毛癣菌基因型VII株PG12DES的基因组特征分析。

我们对临床毛癣菌基因型VII菌株PG12DES的基因组进行了表征。PG12DES基因组含有不同的毒力因子，包括MEP-1、MEP-2、MEP-3、MEP-4、SUB-6和ZAF-A。系统发育分析显示，PG12DES与2017年在摩尔多瓦分离的一株T. mentagrophytes菌株有克隆亲缘关系。本研究提供了来自意大利的临床菌株的基因组特征，拓宽了对新兴基因型VII的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical mycology 医学-兽医学

CiteScore

5.70

自引率

3.40%

发文量

632

审稿时长

12 months

期刊介绍： Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.