γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders.

IF 16.7 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Zhong-Peng Dai, Qiang Wen, Ping Wu, Yan-Ni Zhang, Cai-Lian Fang, Meng-Yuan Dai, Hong-Liang Zhou, Huan Wang, Hao Tang, Si-Qi Zhang, Xiao-Kun Li, Jian-Song Ji, Liu-Xi Chu, Zhou-Guang Wang
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引用次数: 0

Abstract

γ neuromodulation has emerged as a promising strategy for addressing neurological and psychiatric disorders, particularly in regulating executive and cognitive functions. This review explores the latest neuromodulation techniques, focusing on the critical role of γ oscillations in various brain disorders. Direct γ neuromodulation induces γ-frequency oscillations to synchronize disrupted brain networks, while indirect methods influence γ oscillations by modulating cortical excitability. We investigate how monitoring dynamic features of γ oscillations allows for detailed evaluations of neuromodulation effectiveness. By targeting γ oscillatory patterns and restoring healthy cross-frequency coupling, interventions may alleviate cognitive and behavioral symptoms linked to disrupted communication. This review examines clinical applications of γ neuromodulations, including enhancing cognitive function through 40 Hz multisensory stimulation in Alzheimer's disease, improving motor function in Parkinson's disease, controlling seizures in epilepsy, and modulating emotional dysfunctions in depression. Additionally, these neuromodulation strategies aim to regulate excitatory-inhibitory imbalances and restore γ synchrony across neurological and psychiatric disorders. The review highlights the potential of γ oscillations as biomarkers to boost restorative results in clinical applications of neuromodulation. Future studies might focus on integrating multimodal personalized protocols, artificial intelligence (AI) driven frameworks for neural decoding, and global multicenter collaborations to standardize and scale precision treatments across diverse disorders.

γ神经调节:揭示神经和精神疾病的生物标志物。
γ神经调节已成为解决神经和精神疾病的一种有前途的策略,特别是在调节执行和认知功能方面。本文综述了最新的神经调节技术,重点介绍了γ振荡在各种脑部疾病中的关键作用。直接γ神经调节诱导γ频率振荡以同步中断的大脑网络,而间接方法通过调节皮质兴奋性来影响γ振荡。我们研究如何监测γ振荡的动态特征允许神经调节有效性的详细评估。通过靶向γ振荡模式和恢复健康的交叉频率耦合,干预措施可以减轻与沟通中断相关的认知和行为症状。本文综述了γ神经调节的临床应用,包括通过40hz多感觉刺激增强阿尔茨海默病的认知功能,改善帕金森病的运动功能,控制癫痫发作,调节抑郁症的情绪功能障碍。此外,这些神经调节策略旨在调节兴奋性抑制失衡,恢复神经和精神疾病的γ同步。该综述强调了γ振荡作为生物标志物在神经调节临床应用中促进恢复性结果的潜力。未来的研究可能会集中在整合多模式个性化协议,人工智能(AI)驱动的神经解码框架,以及全球多中心合作,以标准化和规模化各种疾病的精确治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Military Medical Research
Military Medical Research Medicine-General Medicine
CiteScore
38.40
自引率
2.80%
发文量
485
审稿时长
8 weeks
期刊介绍: Military Medical Research is an open-access, peer-reviewed journal that aims to share the most up-to-date evidence and innovative discoveries in a wide range of fields, including basic and clinical sciences, translational research, precision medicine, emerging interdisciplinary subjects, and advanced technologies. Our primary focus is on modern military medicine; however, we also encourage submissions from other related areas. This includes, but is not limited to, basic medical research with the potential for translation into practice, as well as clinical research that could impact medical care both in times of warfare and during peacetime military operations.
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