Central Sensitisation, Anxiety and Depressive Symptoms in Patients With Chronic Masticatory Muscle Pain.

IF 4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation Pub Date : 2025-06-26 DOI:10.1111/joor.70007

Piotr Seweryn, Marta Waliszewska-Prosol, Adriana Petrasova, Marta Bort, Milosz Seweryn, Marcin Straburzynski, Mieszko Wieckiewicz

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引用次数: 0

Abstract

Background: Chronic masticatory muscle pain (CMMP), a common symptom of temporomandibular disorders (TMD), is influenced by numerous factors. Central sensitisation (CS) is a significant factor in both chronic pain and temporomandibular disorders. Psychological aspects like anxiety and depression are known to exacerbate pain symptoms. However, the interplay between CS and these factors in CMMP remains unclear.

Objectives: The objective of this study was to evaluate the relationship between CS, anxiety and depressive symptoms in patients with CMMP and to assess how they correlate.

Methods: A total of 206 patients with CMMP underwent a clinical examination following the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) and completed the Central Sensitisation Inventory (CSI), Patient Health Questionnaire-9 (PHQ-9) and Generalised Anxiety Disorder-7 (GAD-7) questionnaires. Pain severity was assessed using the Graded Chronic Pain Scale (GCPS) and the Numeric Rating Scale (NRS). Statistical analyses were conducted to examine correlations and group differences.

Results: Significant correlations were found between CSI and both PHQ-9 (r_s = 0.719, p < 0.001) and GAD-7 (r_s = 0.203, p = 0.003). A higher CSI score correlated with greater intensity of masticatory muscle pain. Women reported significantly higher scores for CS, anxiety and depression than men.

Conclusion: This study highlights a significant relationship between CS, anxiety, depressive symptoms and masticatory muscle pain. These findings underscore the importance of addressing psychological factors and central nervous system dysfunction in managing CMMP to enhance patient outcomes.

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慢性咀嚼肌痛患者的中枢致敏、焦虑和抑郁症状

背景：慢性咀嚼肌疼痛（CMMP）是颞下颌疾病（TMD）的常见症状，受多种因素的影响。中枢致敏（CS）是慢性疼痛和颞下颌疾病的重要因素。众所周知，焦虑和抑郁等心理因素会加剧疼痛症状。然而，在CMMP中，CS与这些因素之间的相互作用尚不清楚。目的：本研究的目的是评估CMMP患者CS、焦虑和抑郁症状之间的关系，并评估它们之间的相关性。方法：206例CMMP患者按照颞下颌疾病诊断标准（DC/TMD）进行临床检查，并完成中枢致敏性量表（CSI）、患者健康问卷-9 （PHQ-9）和广泛性焦虑障碍问卷-7 （GAD-7）。采用分级慢性疼痛量表（GCPS）和数字评定量表（NRS）评估疼痛严重程度。进行统计分析以检验相关性和组间差异。结果：CSI与PHQ-9均有显著相关（rs = 0.719, p s = 0.203, p = 0.003）。CSI评分越高，咀嚼肌疼痛强度越大。女性在CS、焦虑和抑郁方面的得分明显高于男性。结论：本研究强调咀嚼肌疼痛与焦虑、抑郁症状有显著关系。这些发现强调了处理心理因素和中枢神经系统功能障碍在CMMP管理中提高患者预后的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral rehabilitation 医学-牙科与口腔外科

CiteScore

5.60

自引率

10.30%

发文量

116

审稿时长

4-8 weeks

期刊介绍： Journal of Oral Rehabilitation aims to be the most prestigious journal of dental research within all aspects of oral rehabilitation and applied oral physiology. It covers all diagnostic and clinical management aspects necessary to re-establish a subjective and objective harmonious oral function. Oral rehabilitation may become necessary as a result of developmental or acquired disturbances in the orofacial region, orofacial traumas, or a variety of dental and oral diseases (primarily dental caries and periodontal diseases) and orofacial pain conditions. As such, oral rehabilitation in the twenty-first century is a matter of skilful diagnosis and minimal, appropriate intervention, the nature of which is intimately linked to a profound knowledge of oral physiology, oral biology, and dental and oral pathology. The scientific content of the journal therefore strives to reflect the best of evidence-based clinical dentistry. Modern clinical management should be based on solid scientific evidence gathered about diagnostic procedures and the properties and efficacy of the chosen intervention (e.g. material science, biological, toxicological, pharmacological or psychological aspects). The content of the journal also reflects documentation of the possible side-effects of rehabilitation, and includes prognostic perspectives of the treatment modalities chosen.