Age-dependent nonlinear relationship between hypertension and hippocampal volume in sedentary women with lower educational attainment.

IF 1.4 Q3 EDUCATION, SCIENTIFIC DISCIPLINES
Journal of Education and Health Promotion Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI:10.4103/jehp.jehp_1219_24
Sneha Ravichandran, Poovitha Shruthi Paramashiva, Rajagopal Kadavigere, Hari Prakash Palanisamy, K N Shivashankar, Baskaran Chandrasekaran, M G Ramesh Babu, Winniecia Dkhar, Dilip Shettigar, Sathya Sabina Muthu, Suresh Sukumar
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引用次数: 0

Abstract

Background: This study investigated the age-dependent nonlinear relationship between hypertension stages, hippocampal volume, and cognitive performance in sedentary women with lower educational attainment.

Materials and methods: Forty-four women (40-60 years) with low education and physical activity levels underwent Magnetic Resonance Imaging brain scans and cognitive tests. Hippocampal volumes were analyzed using CAT12 and SPM12.

Results: Age-dependent relationships between systolic blood pressure (SBP) and hippocampal volume were observed. In ages 40-49, higher SBP correlated with more minor left hippocampal volumes (r = -0.5937, P = 0.0046). In ages 50-59, greater SBP is associated with larger hippocampal volumes (left: r = 0.7040, P = 0.0002; right: r = 0.5885, P = 0.0031). Hippocampal measurements accounted for 48.2% and 70.3% of SBP variance in younger and older groups, respectively. Higher SBP correlated with poorer cognitive performance in Flanker (reaction time: χ² = 13.87, P = 0.003; accuracy: χ² = 31.36, P < .001) and N-back tasks (reaction time: χ² = 11.63, P = 0.009; accuracy: χ² = 22.20, P < .001).

Conclusion: These findings challenge the "lower is better" blood pressure paradigm, especially in older adults, suggesting the need for age-specific hypertension management and brain health preservation strategies. Public health implications include developing tailored interventions considering age, education, and physical activity; implementing age-specific blood pressure guidelines; integrating cognitive screenings into hypertension care; and creating targeted health literacy programs. Future research should establish causality, explore mechanisms, and evaluate personalized strategies for this vulnerable population.

低学历久坐女性高血压与海马体积的非线性关系。
背景:本研究探讨了低学历久坐女性高血压分期、海马体积和认知表现之间的年龄非线性关系。材料和方法:44名受教育程度和体力活动水平较低的女性(40-60岁)接受了磁共振成像脑部扫描和认知测试。用CAT12和SPM12分析海马体积。结果:观察收缩压(SBP)与海马体积之间的年龄依赖性关系。40 ~ 49岁时,收缩压升高与左侧海马体积减小相关(r = -0.5937, P = 0.0046)。50-59岁,收缩压越大,海马体积越大(左:r = 0.7040, P = 0.0002;右:r = 0.5885, P = 0.0031)。海马测量分别占年轻组和老年组收缩压方差的48.2%和70.3%。较高的收缩压与较差的认知表现相关(反应时间:χ²= 13.87,P = 0.003;准确率:χ²= 31.36,P < 0.001)和N-back任务(反应时间:χ²= 11.63,P = 0.009;准确度:χ²= 22.20,P < .001)。结论:这些发现挑战了“血压越低越好”的观念,特别是在老年人中,表明需要针对特定年龄的高血压管理和脑健康保护策略。对公共卫生的影响包括制定考虑到年龄、教育和身体活动的有针对性的干预措施;实施针对不同年龄的血压指南;将认知筛查纳入高血压护理;创建有针对性的健康素养项目。未来的研究应建立因果关系,探索机制,并评估针对这一弱势群体的个性化策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.60
自引率
21.40%
发文量
218
审稿时长
34 weeks
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