Effective Pseudomonas aeruginosa Eradication in Cystic Fibrosis: Multicenter Study.

IF 0.7 4区医学 Q3 PEDIATRICS

Clinical Pediatrics Pub Date : 2025-11-01 Epub Date: 2025-06-27 DOI:10.1177/00099228251351699

Aynur Guliyeva, Cansu Yilmaz Yegit, Muruvvet Yanaz, Mine Kalyoncu, Merve Selçuk Balcı, Seyda Karabulut, Almala Pınar Ergenekon, Gamze Tastan, Burcu Uzunoglu, Hüseyin Arslan, Hakan Yazan, Gülay Bas Bilgin, Ebru Köstereli, Ayse Ayzıt Kılınc Sakallı, Erkan Cakır, Saniye Girit, Zeynep Seda Uyan, Yasemin Gokdemir, Ela Erdem Eralp, Fazilet Karakoc, Bulent Karadag

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引用次数: 0

Abstract

Background: Pseudomonas aeruginosa (PA) eradication is crucial in cystic fibrosis (CF) management. At our center, the success rate was 21.6%, prompting a revised eradication protocol to evaluate a new regimen.

Methods: Cystic fibrosis patients with first-time PA detection were included. Nonmucoid PA cases received oral ciprofloxacin (3 weeks) and inhaled tobramycin (1 month). For mucoid PA or failed eradication, ciprofloxacin (3 weeks) and extended nebulized therapy (3 months, alternating tobramycin/colistin) were used. Intravenous antibiotics were given to unwell patients.

Results: Among 109 CF patients (median age: 6 years), 79 (72.5%) achieved successful eradication. Oral ciprofloxacin and tobramycin inhalation were used in 66 patients (60.6%), extended nebulized therapy in 26 (23.8%), and intravenous antibiotics in 17(15.6%).

Conclusion: The revised protocol achieved a high PA eradication rate in CF patients. Adapting treatment regimens based on PA characteristics and patient condition can optimize outcomes and improve CF management.

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有效根除铜绿假单胞菌在囊性纤维化：多中心研究。

背景：铜绿假单胞菌（PA）的根除是囊性纤维化（CF）治疗的关键。在我们的中心，成功率为21.6%，促使修订根除方案以评估新方案。方法：纳入首次检出PA的囊性纤维化患者。非黏液样PA患者口服环丙沙星（3周），吸入妥布霉素（1个月）。对于黏液性PA或根除失败，使用环丙沙星（3周）和延长雾化治疗（3个月，妥布霉素/粘菌素交替）。对身体不适的病人静脉注射抗生素。结果：109例CF患者（中位年龄：6岁）中，79例（72.5%）成功根除。口服环丙沙星和妥布霉素吸入66例（60.6%），延长雾化治疗26例（23.8%），静脉注射抗生素17例（15.6%）。结论：修订后的方案在CF患者中实现了较高的PA根除率。根据PA特征和患者病情调整治疗方案可以优化结果并改善CF管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Pediatrics 医学-小儿科

CiteScore

2.10

自引率

6.20%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical Pediatrics (CLP) a peer-reviewed monthly journal, is a must read for the busy pediatrician. CLP contains state-of-the-art, accurate, concise and down-to earth information on practical, everyday child care topics whether they are clinical, scientific, behavioral, educational, or ethical.