Analysis of circRNA characteristics and identification of key circRNAs in the hypothalamus during sexual maturation in female goats.

IF 2.5 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal Bioscience Pub Date : 2025-06-24 DOI:10.5713/ab.25.0275

Qing Li, Jian-Min Wang, Yanyan Wang, Peipei He, Lu Zhang, Tianle Chao

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引用次数: 0

Abstract

Objective: Precocious puberty can shorten reproductive cycles, enhance reproductive capacity, and reduce feeding costs. Consequently, precocious livestock are widely utilized in cross-breeding. This study aims to elucidate the key molecular mechanisms by which circular RNA (circRNA) regulates the sexual maturation of sexually precocious goats.

Methods: In this study, we analyzed the circRNA expression profiles of hypothalamic tissue from Jining grey goats at four distinct postnatal developmental stages (1 day, 2 months, 4 months, 6 months).

Results: A total of 23,993 circRNAs were identified across these stages, predominantly derived from exonic regions, with 1,052 circRNAs exhibiting differential expression. Additionally, competitive endogenous RNA (ceRNA) analysis suggested that novel_circ_0002274/chi-miR-197-5p/ estrogen receptor 1 (ESR1) and novel_circ_0002274/chi-miR-30c-3p/ oxytocin/neurophysin I prepropeptide (OXT) may regulate sexual maturation in goats via the estrogen signaling pathway and the oxytocin signaling pathway.

Conclusion: This study contributes to understanding the function of circRNAs in hypothalamic regulation of sexual maturation and provides valuable insights for breeding superior goat breeds.

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雌性山羊性成熟过程中下丘脑环状rna特征分析及关键环状rna鉴定。

目的：性早熟可缩短生殖周期，增强生殖能力，降低饲养成本。因此，早熟家畜在杂交育种中得到了广泛的应用。本研究旨在阐明环状RNA （circRNA）调控性早熟山羊性成熟的关键分子机制。方法：在本研究中，我们分析了吉宁灰山羊在出生后4个不同发育阶段（1天、2个月、4个月、6个月）下丘脑组织的circRNA表达谱。结果：在这些阶段共鉴定出23,993个circrna，主要来自外显子区域，其中1,052个circrna表现出差异表达。此外，竞争性内源性RNA （ceRNA）分析表明，novel_circ_0002274/chi- mir - 197,5p /雌激素受体1 （ESR1）和novel_circ_0002274/chi-miR-30c-3p/催产素/神经physin I前肽（OXT）可能通过雌激素信号通路和催产素信号通路调节山羊性成熟。结论：本研究有助于了解circRNAs在下丘脑性成熟调控中的功能，为培育优良山羊品种提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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