Rheological Characterization of Different Fat-Derived Products.

IF 3 2区医学 Q1 SURGERY

Aesthetic Surgery Journal Pub Date : 2025-06-19 DOI:10.1093/asj/sjaf066

Mingheng Xue, Qian Zhang, Xinhui Wang, Juzi Liu, Zhixin Xue, Feng Lu, Yunjun Liao, Junrong Cai

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引用次数: 0

Abstract

Background: Fat grafting has been widely used to correct soft-tissue volume loss and facial rejuvenation. Recent innovative advances have led to different types of fat-derived products. Although the composition of cells and extracellular matrix within different fat products has been reported, their physical and rheological properties are poorly defined.

Objectives: The authors of this study aim to evaluate the rheological properties of different fat-derived products and assess how these properties change after transplantation.

Methods: In this study, the authors assessed the rheological properties of 4 fat-derived products-adipose matrix complex AMCs, high-density fat (HDF), stromal vascular fraction-gel (SVF-gel), and Coleman fat-before and after transplantation. Key parameters, including elastic modulus (G'), viscous modulus (G″), tan delta (tan δ), and yield stress (τy), were measured using a rheometer.

Results: Before transplantation, AMC exhibited the highest G' and G″, followed by SVF-gel, HDF, and Coleman fat. After transplantation, G' decreased for all products, indicating reduced elasticity, while G″ increased, suggesting increased viscosity. AMC maintained the highest G' and G″ even after 3 months, with SVF-gel and HDF showing similar values. Coleman fat had the lowest G' and G″ at all time points.

Conclusions: Fat-derived products have distinct clinical applications based on their mechanical properties. AMC is ideal for deep structural support, SVF-gel for superficial corrections, and HDF for volume restoration in midface areas with volume loss. Clinicians should select products based on mechanical properties and anatomical needs to optimize outcomes.

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不同脂肪衍生产品的流变学特性。

背景：脂肪移植已被广泛应用于软组织体积缩小和面部年轻化。最近的创新进步导致了不同类型的脂肪衍生产品。虽然已经报道了不同脂肪产品中细胞和细胞外基质的组成，但它们的物理和流变特性却没有明确的定义。目的：本研究的作者旨在评估不同脂肪源性产品的流变特性，并评估这些特性在移植后的变化。方法：在这项研究中，作者评估了4种脂肪衍生产品——脂肪基质复合物（AMCs）、高密度脂肪（HDF）、基质血管组分凝胶（svf -凝胶）和Coleman脂肪——移植前后的流变学特性。关键参数包括弹性模量（G′），粘性模量（G″），tan δ (tan δ)和屈服应力（τy），使用流变仪进行测量。结果：移植前，AMC的G′和G″最高，其次是SVF-gel、HDF和Coleman fat。移植后，所有产品的G′均减小，表明弹性降低，而G″增大，表明粘度增加。AMC在3个月后仍保持最高的G′和G″，SVF-gel和HDF的值相近。科尔曼脂肪在所有时间点的G′和G″最低。结论：基于其机械性能，脂肪衍生产品具有独特的临床应用。AMC是深层结构支撑的理想选择，svf -凝胶用于表面矫正，HDF用于面部中部体积损失区域的体积恢复。临床医生应根据机械性能和解剖需要选择产品，以优化结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aesthetic Surgery Journal SURGERY-

CiteScore

6.20

自引率

20.70%

发文量

309

审稿时长

6-12 weeks

期刊介绍： Aesthetic Surgery Journal is a peer-reviewed international journal focusing on scientific developments and clinical techniques in aesthetic surgery. The official publication of The Aesthetic Society, ASJ is also the official English-language journal of many major international societies of plastic, aesthetic and reconstructive surgery representing South America, Central America, Europe, Asia, and the Middle East. It is also the official journal of the British Association of Aesthetic Plastic Surgeons, the Canadian Society for Aesthetic Plastic Surgery and The Rhinoplasty Society.