Identification of Schwann Cells in Human Intracranial Arteries: Potential Regulatory Role in Atherosclerotic Plaque Progression.

IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Zijue Wang, Yangzhige He, Weizhuang Yuan, Yijun Xia, Manqiu Ding, Zhen Chen, Naili Wang, Chao Ma, Xiaoyue Wang, Yan Xu, Weihai Xu
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引用次数: 0

Abstract

Intracranial atherosclerosis (ICAS), a common cause of ischemic stroke, remains a therapeutic challenge due to complex intracranial anatomy and intervention risks. Although ICAS develops intracranially, cerebral artery innervation originates in the peripheral nervous system. The scarcity of human intracranial specimens has hindered investigations into the potential role of Schwann cells (SCs) in neurovascular homeostasis. Using multimodal analysis of plaque-bearing and non-plaque-bearing intracranial artery samples from the same postmortem individuals (n = 16 donors), SCs associated with myelinated neural structures are identified. Quantitative ultrastructural evaluation reveals a 4.3-fold increase in SC-derived myelin sheaths within plaque-bearing vessels (P <0.001). Single-cell RNA sequencing (scRNA-seq) of SCs demonstrates significant upregulation of genes involved in axonogenesis, axon ensheathment, axon guidance, synaptic transmission, and synaptic integration. Cell-cell communication analysis shows enhanced interactions between SCs and vascular smooth muscle cells (VSMCs) in plaque-bearing vessels. Synaptic-like structures are observed in the walls of intracranial arteries, along with a 2.9-fold increase in VSMC-innervating myelinated fibers (P <0.001). Ligand-receptor analysis indicates SPP1-ITGB1 signaling as a potential mediator of SCs-VSMCs crosstalk. This study provides evidence for the involvement of SCs in ICAS pathobiology and proposes novel neurovascular targets for precision therapies in cerebrovascular disease.

人颅内动脉中雪旺细胞的鉴定:在动脉粥样硬化斑块进展中的潜在调节作用。
颅内动脉粥样硬化(ICAS)是缺血性脑卒中的常见病因,由于颅内复杂的解剖结构和干预风险,仍然是治疗上的挑战。虽然ICAS发生于颅内,但脑动脉神经支配起源于周围神经系统。人类颅内标本的缺乏阻碍了对雪旺细胞(SCs)在神经血管稳态中的潜在作用的研究。通过对来自同一死后个体(n = 16个供体)的含斑块和非含斑块颅内动脉样本进行多模态分析,确定了与髓鞘神经结构相关的SCs。定量超微结构评估显示,斑块血管内sc来源的髓鞘增加了4.3倍
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来源期刊
Advanced Science
Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
18.90
自引率
2.60%
发文量
1602
审稿时长
1.9 months
期刊介绍: Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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