Composition Engineering for Enhanced Photosensitization: A Toolbox for Biological Applications

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-07-14 DOI:10.1021/acs.biomac.5c00659

Mengyao Zhang , Jingbo Huang , Shunze Cheng , Yujie Bai , Pei Huang , Haili Zhang , Shunjie Liu , Hualei Wang , Yuanyuan Li

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Abstract

Conjugated polymers (CPs) exhibiting aggregation-induced emission (AIE) properties have found extensive applications in the biomedical sector due to their strong solid-state emission, enhanced light absorption capabilities, and effective production of reactive oxygen species (ROS). However, an explanation of the structure–function relationship was not provided. Herein, four CPs with AIE characteristics were synthesized by varying the composition and combination of donor–acceptor (D–A), among which PADAD’ exhibited the highest ROS generation efficiency due to its D–A effect and aggregation-induced ROS generation ability. Furthermore, functionalized CPs were designed as a toolbox for biological applications using PADAD’ as the skeleton. As a proof of concept, PADAD’-APT and PADAD’-GUA were synthesized by introducing target motifs designed to identify and photoinactivate tumor cells and bacteria, respectively. Thus, this platform holds great promise for biomedicine and provides ideas for the development of functionalized conjugated polymers.

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增强光敏化的成分工程：生物应用工具箱。

共轭聚合物（CPs）具有聚集诱导发射（AIE）特性，由于其强大的固态发射、增强的光吸收能力和有效的活性氧（ROS）产生，在生物医学领域得到了广泛的应用。然而，没有提供结构-功能关系的解释。本文通过改变供体-受体（D-A）的组成和组合，合成了四种具有AIE特征的CPs，其中PADAD’由于其D-A效应和聚集诱导的ROS生成能力，表现出最高的ROS生成效率。此外，功能化cp被设计成一个工具箱，用于生物应用，使用PADAD'作为骨架。作为概念的证明，PADAD'-APT和PADAD'-GUA分别通过引入旨在识别和光灭活肿瘤细胞和细菌的靶基序合成。因此，该平台在生物医学领域具有很大的前景，并为功能化共轭聚合物的发展提供了思路。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.