Near Infrared Light-Triggered Small Molecule Chemical Reactions in Biocompatible Systems.

IF 3.9 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2025-07-16 Epub Date: 2025-06-27 DOI:10.1021/acs.bioconjchem.5c00293

Jie Zhong, Yuhang Li, Xiaotong Li, Feng Liang, Ran Tao, Shan Qian, Xinyuan Fan

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引用次数: 0

Abstract

Near-infrared (NIR) light, within the 700-1000 nm therapeutic optical window, offers deep tissue penetration, low photocytotoxicity, and minimal side effects, making it ideal for remote control of biocompatible reactions in vivo. This review explores recent advances in NIR-triggered reactions, focusing on direct and indirect activation strategies. Direct approaches utilize NIR-responsive protecting groups, while indirect methods employ upconversion materials and photocatalysis to overcome NIR's energy limitations. These innovations expand noninvasive in vivo control capabilities. Applications include NIR-mediated drug delivery, biological molecule activation, and proximity labeling for protein interaction studies. Such reactions enable precise modulation of biological events under native conditions. The review highlights the potential of integrating advanced nanomaterials and optimizing indirect activation techniques to enhance reaction efficiency. It also emphasizes the requirement for interdisciplinary collaboration to refine NIR-responsive systems and facilitate clinical translation. By showcasing state-of-the-art NIR-controlled chemistry and identifying key areas for future research, this work aims to inspire advancements in biomedical research and therapeutics. Addressing the challenges of in vivo chemical control, this review positions NIR chemistry as a critical component in the evolution of biocompatible reaction methodologies.

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生物相容性系统中近红外光触发的小分子化学反应。

近红外（NIR）光，在700-1000 nm的治疗光学窗口内，提供深层组织穿透，低光细胞毒性和最小的副作用，使其成为远程控制体内生物相容性反应的理想选择。本文综述了nir触发反应的最新进展，重点是直接和间接激活策略。直接方法利用近红外响应保护基团，而间接方法采用上转换材料和光催化来克服近红外的能量限制。这些创新扩大了非侵入性体内控制能力。应用包括nir介导的药物传递、生物分子激活和蛋白质相互作用研究的接近标记。这种反应使在自然条件下精确调节生物事件成为可能。综述强调了集成先进纳米材料和优化间接活化技术以提高反应效率的潜力。它还强调了跨学科合作的需求，以完善nir响应系统并促进临床翻译。通过展示最先进的nir控制化学和确定未来研究的关键领域，这项工作旨在激发生物医学研究和治疗学的进步。针对体内化学控制的挑战，本综述将近红外化学定位为生物相容性反应方法发展的关键组成部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.