Chiwoo Oh, Han Na Jung, Jiwoo Park, John Mark Awad, Dawei Jiang, David J Dowling, Hyung-Jun Im
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引用次数: 0
Abstract
The spleen, which is the largest lymphoid organ, contains various immune cells and plays a crucial role in immunological responses. Because nanoparticles have a natural characteristic of being taken up by reticuloendothelial system (RES) organs, including the spleen, various spleen-targeting nanomedicine strategies have been developed for immunomodulatory therapies. Herein, we review the biological role of the spleen as part of the immune system, types of spleen-targeting nanoparticles, considerations for engineering both current and innovative spleen-targeting strategies, and their therapeutic potential in various diseases, including tumors and autoimmune diseases. Furthermore, we discuss the importance of systems immunology based approaches, including spatial transcriptomics, in achieving a comprehensive understanding of spleen-targeting strategies using nanomedicine.
期刊介绍：
ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.
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