Can digestive biomarkers detect early effects of bifenthrin exposure in native fish?

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-06-25 DOI:10.1016/j.etap.2025.104751

Andrea S. Rossi , Carla Bacchetta , Celeste Mora , Melina P. Michlig , María Rosa Repetti , Jimena Cazenave

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引用次数: 0

Abstract

The digestive health of fish is directly related to their ability to process food and therefore, to their welfare and growth performance. However, the digestive tract of fish is also one of the main routes of entry for pesticides, which could ultimately affect metabolism. The aim of this study was to assess the responses of digestive biomarkers in two native and commercially important fish species confined in cages in a rice field during a bifenthrin (BF) application. Two cages per species were placed at each experimental site: the control site and the site where BF was sprayed (Seizer®; 100 cm³ ha⁻¹). At 72 h after application, morphological and biochemical biomarkers, the intestinal accumulation of BF and digestive enzyme activities in different tissues were evaluated in Hoplosternum littorale and Piaractus mesopotamicus. Short-term in situ exposure caused increased plasma glucose levels and intestinal accumulation of BF in both fish species, without changes in condition factor or hepatosomatic index. Lower lipase and amylase activities were observed in the intestinal tissue of P. mesopotamicus while H. littorale showed no enzymatic changes. Digestive biomarker enzymes could be used as early warning tools to reflect the health status of sensitive fish in rice-fish cocultures predicting economic implications for producers.

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消化生物标志物能否检测本地鱼类接触联苯菊酯的早期影响？

鱼类的消化系统健康直接关系到它们处理食物的能力，因此关系到它们的福利和生长性能。然而，鱼类的消化道也是农药进入的主要途径之一，最终会影响新陈代谢。本研究的目的是评估在施用联苯菊酯（BF）期间稻田笼养的两种本地和商业上重要的鱼类的消化生物标志物的反应。每个实验地点每个物种放置两个笼子：对照地点和喷BF的地点(Seizer®；100厘米³农业)。在施用后72h，对小胸鼠和美索不达河鼠进行形态学和生化生物标志物、肠道BF积累和不同组织消化酶活性的测定。短期原位暴露导致两种鱼类的血糖水平和肠道BF积累增加，但没有改变条件因子或肝体指数。两河鼠肠道组织中脂肪酶和淀粉酶活性较低，而河鼠肠道组织中酶活性无明显变化。消化生物标记酶可以作为早期预警工具，反映水稻-鱼共养殖中敏感鱼的健康状况，预测对生产者的经济影响。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.