Iridium-Bismuth-Oxide Coatings for Use in Neural Stimulating Electrodes: The Influence of Ir/Bi Ratio

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part A Pub Date : 2025-06-27 DOI:10.1002/jbm.a.37956

Xingge Xu, Irshad Ali, Sandra Minotti, Heather D. Durham, Sasha Omanovic

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Abstract

Implantable neural prosthetics with stimulating electrodes are increasingly employed in medical practices to treat neural disabilities. The electrode material is expected to provide high charge storage and injection capacity (CSC/CIC) and low impedance for safe, efficient, and precise neural stimulation, while at the same time, being small. To improve the current state-of-the-art neural-electrode material, iridium oxide (IrOx), Ir_mBi_1-mOx coatings of various compositions (m = 0, 0.2, 0.4, 0.6, 0.8, and 1.0) produced by thermal deposition were evaluated. The Ir_0.8Bi_0.2Ox yielded a CSC of 17.7 ± 1.1 mC/cm², which is four-fold higher than that of IrOx. At the same time, the impedance of Ir_0.8Bi_0.2Ox at 1 kHz was measured to be half of that of IrOx. The superior performance of Ir_0.8Bi_0.2Ox was explained by forming amorphous structures that facilitate the intercalation of H⁺ and OH⁻ ions into deeper oxide structures that contribute to faradaic charge storage. The Ir_0.8Bi_0.2Ox electrode also showed good stability and biocompatibility, which makes it potentially a good candidate for neural stimulating electrodes.

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用于神经刺激电极的氧化铱铋涂层：Ir/Bi比的影响

具有刺激电极的植入式神经假体越来越多地应用于治疗神经功能障碍的医疗实践中。该电极材料有望提供高电荷存储和注射容量（CSC/CIC）和低阻抗，以实现安全、高效、精确的神经刺激，同时体积小。为了改进当前最先进的神经电极材料，氧化铱（IrOx），对热沉积生产的各种成分（m = 0, 0.2, 0.4, 0.6, 0.8和1.0）的IrmBi1-mOx涂层进行了评估。Ir0.8Bi0.2Ox的CSC为17.7±1.1 mC/cm2，是IrOx的4倍。同时，测量了Ir0.8Bi0.2Ox在1khz时的阻抗为IrOx的一半。Ir0.8Bi0.2Ox之所以具有优异的性能，是因为其形成的非晶结构有助于H+和OH−离子嵌入更深的氧化物结构，从而有助于法拉第电荷的存储。Ir0.8Bi0.2Ox电极具有良好的稳定性和生物相容性，是神经刺激电极的潜在候选材料。

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来源期刊

Journal of biomedical materials research. Part A 工程技术-材料科学：生物材料

CiteScore

10.40

自引率

2.00%

发文量

135

审稿时长

3.6 months

期刊介绍： The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device. The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.