Multifunctional photosensitizer as apoptosis and ferroptosis inducer for photodynamic and photothermal immunotherapy

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-06-27 DOI:10.1016/j.dyepig.2025.112996

Jie Zeng , Miao-Yan Xu , Xin-Hao Han , Zheng-Bin Xiang , Duo-Duo Wei , Bing Fan , Xing Wang , Xin-Hui Qu , Xiao-Jian Han , Shaorong Huang

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引用次数: 0

Abstract

Multifunctional single component photosensitizer (PS) and muti-modal cell death induced immune activation represents a promising strategy for anti-tumor therapy. Herein, an acceptor-π-donor-π-acceptor (A-π-D-π-A) configuration of side chain sp3 hybridization carbon atom and conjugated fused-ring skelecton strategy was proposed to balance fluorescence imaging (FLI), photothermal and photodynamic properties. As the results, FCT nanoparticles (FCT NPs) displayed FLI performance, superior photothermal conversion efficiency (PCE) up to 80.79 %, as well as reactive oxygen species (ROS) generation capacity, especially Type I photodynamic therapy (PDT) which can produce highly-reactive hydroxyl radical (^● OH) and superoxide anion (O₂^• ⁻) in hypoxia environment. Importantly, FCT NPs + NIR possessed remarkable ability to ablate tumor mainly induced by apoptosis/ferroptosis, provoking immunogenic cell death (ICD) to enhance the maturation of dendritic cells (DCs) and further present antigens to T cells, which activated anti-tumor immune responses and high-effectively prevents the lung metastasis of tumor. In sum, our work introduced single component photosensitizers of apoptosis/ferroptosis for potent photodynamic and photothermal immunotherapy for metastatic tumors.

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多功能光敏剂作为光动力和光热免疫治疗的凋亡和铁下垂诱导剂

多功能单组分光敏剂（PS）和多模态细胞死亡诱导免疫激活是一种很有前途的抗肿瘤治疗策略。本文提出了侧链sp3杂化碳原子的受体-π-给体-π-受体（A-π-D-π-A）构型和共轭融合环骨架策略，以平衡荧光成像（FLI）、光热和光动力性能。结果表明，FCT纳米颗粒（FCT NPs）具有良好的FLI性能，光热转换效率（PCE）高达80.79%，并具有活性氧（ROS）生成能力，特别是在缺氧环境下可产生高活性羟基自由基（●OH）和超氧阴离子（O2•−）的I型光动力疗法（PDT）。重要的是，FCT NPs + NIR具有显著的消融主要由凋亡/铁凋亡诱导的肿瘤的能力，引发免疫原性细胞死亡（immunogenic cell death， ICD），促进树突状细胞（dendritic cells, dc）的成熟，并进一步向T细胞呈递抗原，激活抗肿瘤免疫应答，高效地阻止肿瘤的肺转移。总之，我们的工作介绍了细胞凋亡/铁下垂的单组分光敏剂用于转移性肿瘤的强效光动力和光热免疫治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.