Early Scedosporium apiospermium infection of a soil-contaminated traumatic injury successfully treated with isavuconazole: A case report

Abstract

Scedosporium apiospermium, a rare fungal pathogen from soil and stagnant water, can cause invasive infections, particularly in immunocompromised patients. An 83-year-old male with a soil-contaminated traumatic wound developed persistent inflammation despite antibiotic therapy. Scedosporium apiospermium was identified, and systemic isavuconazole led to significant wound improvement after eight weeks. This case emphasizes the need to consider fungal infections in traumatic wounds. Isavuconazole was effective and safe, offering a valuable alternative to voriconazole