Correlation of ferritin autophagy mediated by NCOA4 in type 2 diabetes with nonalcoholic fatty liver: Thermal radiation biomedical imaging testing

Abstract

The emerging thermal radiation biomedical imaging technology provides an effective means of non-invasive monitoring of pathological status. This study evaluated the application value of thermal radiation biomedical imaging technology in observing NCOA4 mediated ferritin autophagy in patients with type 2 diabetes combined with NAFLD, and analyzed its relationship with biochemical indicators. The study included multiple type 2 diabetes patients with NAFLD and the control group. Quantitative analysis is conducted using thermal radiation biomedical imaging, combined with general data recording and biochemical index determination. By measuring the expression level of NCOA4 and the autophagy activity of ferritin, the effects of high glucose and high-fat conditions on liver cells were observed, and cell survival status was evaluated using cell mortality rate. The general information of the three groups of patients shows that the biochemical indicators of the comorbidities group are significantly higher than those of the control group, especially in terms of liver function and glucose metabolism related indicators. The thermal radiation imaging results showed that under glucose and lipid conditions, the expression of NCOA4 was significantly upregulated, and the occurrence of ferritin autophagy was promoted. Under high sugar and high-fat conditions, NCOA4 mediated ferritin phagocytosis significantly increased cell mortality. Therefore, thermal radiation biomedical imaging provides an effective non-invasive means for evaluating ferritin autophagy in type 2 diabetes patients with NAFLD. The research results indicate that NCOA4 plays an important regulatory role in this pathological state, which can affect cell survival and metabolism.