Gene prediction link between metabolite-mediated inflammatory factors and vertigo

Abstract

Objective

To explore the causal relationship between inflammatory factors and vertigo diseases, and to determine and quantify the role of 1400 metabolites as potential mediators.

Methods

Using the summary data of the whole genome association study(genome-wide association study, GWAS), two-sample Mendel randomization(Mendelian randomization, MR)analysis was performed on four vertigo diseases and 1400 inflammatory factors predicted by genes.Furthermore, we used two-step MR to quantify the effects of 1400 metabolite-mediated inflammatory factors on vertigo.

Results

MR analysis identified higher genes predicted inflammatory factors to increase the risk of vertigo. Reverse studies of inflammatory factors on vertigo have shown that gene-predicted vertigo has no effect on most of the selected inflammatory factors. Metabolites-mediated gene predictions are more associated with inflammatory factors, and mediating effects lack strong evidence support.

Conclusion

In summary, our study identified a causal relationship between inflammatory factors and vertigo, where the proportion of effects mediated by blood metabolites and other metabolites is small, but the majority of the effects of inflammatory factors on vertigo remain unclear. Additional risk factors as potential mediating factors require further research. In clinical practice, blood test indicators for patients with vertigo deserve in-depth exploration.