Role of activating transcription factor 3 in breast cancer progression: Tumor suppressor and oncogene perspectives

IF 0.9 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2025-06-27 DOI:10.1016/j.genrep.2025.102284

Dilipkumar Preetha, Iyyappan Saranya, Nagarajan Selvamurugan

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引用次数: 0

Abstract

The adaptive response network uses activating transcription factor 3 (ATF3) as a central regulator, responding to stress signals. Basal levels of ATF3 expression maintain cellular homeostasis under normal physiological conditions. Various pathological conditions, including breast cancer, alter ATF3 expression through distinct regulatory mechanisms during disease progression. ATF3 acts as a tumor suppressor gene or an oncogene in a context-dependent manner. Particularly in breast cancer, ATF3 plays a multifaceted role by regulating cell proliferation, apoptosis, invasion, metastasis, and therapy resistance. The tumor microenvironment strongly influences ATF3 expression by modulating the immune landscape. Therefore, this review provides a brief overview of the influences on ATF3 expression and its interactions with key tumor-suppressive and oncogenic pathways in breast cancer. A more profound understanding of ATF3 and its role in breast cancer is crucial for the development of personalized therapeutic strategies to address the challenges posed by the heterogeneity of the disease.

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激活转录因子3在乳腺癌进展中的作用：肿瘤抑制因子和癌基因的观点

自适应反应网络使用激活转录因子3 （ATF3）作为中央调节器，对应激信号作出反应。在正常生理条件下，ATF3的基础表达水平维持细胞内稳态。在疾病进展过程中，包括乳腺癌在内的各种病理状况通过不同的调节机制改变ATF3的表达。ATF3以环境依赖的方式作为肿瘤抑制基因或致癌基因。特别是在乳腺癌中，ATF3通过调节细胞增殖、凋亡、侵袭、转移和治疗抵抗等发挥着多方面的作用。肿瘤微环境通过调节免疫景观强烈影响ATF3的表达。因此，本文就乳腺癌中ATF3表达的影响及其与关键抑瘤和致癌途径的相互作用作一综述。更深入地了解ATF3及其在乳腺癌中的作用对于制定个性化治疗策略以应对该疾病异质性带来的挑战至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.