Stereotactic radiosurgery for optic nerve sheath meningiomas: A comprehensive systematic review and meta-analysis

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Clinical Neuroscience Pub Date : 2025-06-27 DOI:10.1016/j.jocn.2025.111432

Bardia Hajikarimloo , Salem M. Tos , Ibrahim Mohammadzadeh , Kimiya Shahabi , Mohammadreza Amjadzadeh , Zahra Golkar , Mohammadamin Sabbagh Alvani , Mohammad Amin Habibi

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引用次数: 0

Abstract

Background

Optic nerve sheath meningiomas (ONSMs) are rare brain neoplastic lesions that account for 2% of meningiomas. Despite the benign and slow-growing behavior of ONSMs, these lesions can result in irreversible blindness. Radiotherapy (RT) is one of the main therapeutic options for the management of ONSMs. Stereotactic radiosurgery (SRS) has demonstrated favorable outcomes in patients with ONSMs. This systematic review and meta-analysis aimed to evaluate local control (LC), preservation of visual field (VF)/visual acuity (VA), and radiation-induced neuropathy/retinopathy.

Methods

On March 17, 2025, four electronic databases, PubMed, Embase, Scopus, and Web of Science, were searched. Studies that evaluated the efficacy and safety of SRS in ONSMs were included.

Results

Seven studies involving 149 patients were included. The mean follow-up duration ranged from 30 to 116.86 months. The meta-analysis reported a pooled LC rate of 95 % (95 % CI: 90 %-98 %). The pooled estimates for VA and VF preservation were 91 % (95 % CI: 76 %-100 %) and 94 % (95 % CI: 68 %-100 %), respectively. Additionally, the meta-analysis found a pooled radiation-induced neuropathy/retinopathy rate of 0 % (95 % CI: 0 %-3%).

Conclusion

SRS demonstrated promising clinical and radiological outcomes in patients with ONSMs. SRS has comparable results to those of the other RT modalities. Further studies with large sample sizes are required to compare SRS and RT modalities.

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立体定向放射外科治疗视神经鞘脑膜瘤：一项全面的系统回顾和荟萃分析

背景：前突神经鞘脑膜瘤是一种罕见的脑肿瘤，约占脑膜瘤的2%。尽管ONSMs表现为良性且生长缓慢，但这些病变可导致不可逆转的失明。放射治疗（RT）是治疗ONSMs的主要治疗选择之一。立体定向放射手术（SRS）在ONSMs患者中显示出良好的结果。本系统综述和荟萃分析旨在评估局部控制（LC）、视野(VF)/视力（VA）的保存和辐射诱发的神经病变/视网膜病变。方法于2025年3月17日检索PubMed、Embase、Scopus和Web of Science 4个电子数据库。评估SRS在ONSMs中的有效性和安全性的研究被纳入。结果纳入7项研究，共149例患者。平均随访时间30 ~ 116.86个月。荟萃分析报告合并LC率为95% （95% CI: 90% - 98%）。VA和VF保存的汇总估计分别为91% （95% CI: 76% - 100%）和94% （95% CI: 68% - 100%）。此外，荟萃分析发现放射诱导的神经病变/视网膜病变发生率为0% （95% CI: 0% -3%）。结论srs对ONSMs患者具有良好的临床和放射学效果。SRS的结果与其他放疗方式相当。需要进一步的大样本量研究来比较SRS和RT模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Neuroscience 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

402

审稿时长

40 days

期刊介绍： This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology. The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.